哌拉西林钠他唑巴坦钠致大疱表皮松解型药疹一例

A case of epidermolysis bullosa drug eruption caused by piperacillin sodium and tazobactam sodium

目的探讨患者发生大疱表皮松解型药疹的起因。方法梳理患者的诊疗经过,通过药物筛查、不良反应发生时间关联情况进行分析,探讨患者发生严重药品不良反应的原因。结果可疑药物包括泮托拉唑肠溶胶囊、哌拉西林钠他唑巴坦钠,经关联性评价对可疑药物的判断分别为“可能”、“很可能”。结论哌拉西林钠他唑巴坦钠致大疱表皮型松解型药疹属非常罕见,易被忽略,应引起临床重视。

Objective To investigate the causes of epidermolysis bullosa drug eruption in patients.Methods The diagnosis and treatment process of the patients was sorted out,and the correlation between drug screening and adverse drug reaction time was analyzed to explore the causes of serious adverse drug reactions in patients.Results The suspicious drugs included pantoprazole enteric-coated capsules,piperacillin sodium and tazobactam sodium,which were judged as"possible"and"probable"respectively after correlation evaluation.Conclusion The epidermolysis of bullae caused by piperacillin sodium and tazobactam sodium is very rare,easy to be ignored,and should be paid attention to in clinic.