中性粒细胞胞外捕获网防御机制的研究进展

Research progress on defense mechanism of neutrophil extracellular traps

中性粒细胞作为先天免疫的吞噬细胞,在免疫防御中起核心作用。中性粒细胞胞外捕获网(NETs)的发现使中性粒细胞再次成为研究热点。NETs通过其内含的抗菌肽和诸多的酶系统进行捕获、抑制和杀灭病原微生物。NETs参与炎症和多种自身免疫调节疾病的发生发展。文章就NETs的形成机制以及NETs的宿主防御作用展开综述,以期为相关研究及应用提供参考。

As innate immune phagocytes,neutrophils play a important role in immune defense.The discovery of neutrophil extracellular traps(NETs)makes neutrophils becoming a hot topics again.NETs can capture,inhibit and kill pathogenic microorganisms through its antibacterial peptides and many enzyme systems.Many studies have found that NETs are involved in the occurrence and development of inflammation and a variety of autoimmune diseases.The article reviews the formation mechanism of NETs and the host defense role of NETs,in order to provide reference for related research and application.