非阻塞性冠状动脉疾病的冠状动脉微循环功能障碍治疗新进展

Treatment of Coronary Microvascular Dysfunction in Non-Obstructive Coronary Artery Disease

冠状动脉微循环功能障碍(CMVD)是指冠状动脉微血管结构和/或功能异常,导致冠状动脉血流量及心肌灌注量减少,增加心血管事件风险,严重影响患者的生存率和预后。在中国,CMVD治疗多为经验性的,有6.3%的冠状动脉微循环病变患者获得正确治疗。近年,非阻塞性冠状动脉疾病的CMVD研究增多,发现一些药物对其具有潜在的治疗意义,现就非阻塞性冠状动脉疾病的CMVD治疗进展做一综述。

Coronary microvascular dysfunction(CMVD)refers to the abnormal structure and/or function of coronary microvessels,which leads to the decrease of coronary blood flow and myocardial perfusion,increases the risk of cardiovascular events,and seriously affects the survival rate and prognosis of patients.In China,the treatment of CMVD is mostly empirical,and 6.3%of patients with coronary microcirculation lesions receive correct treatment.In recent years,the research on CMVD of non-obstructive coronary artery disease has increased,and some drugs have potential therapeutic significance.This paper reviews the progress of CMVD treatment of non-obstructive coronary artery disease.