射血分数保留性心力衰竭潜在的分子机制及治疗靶点

Potential Molecular Mechanisms and Therapeutic Target in Heart Failure with Preserved Ejection Fraction

射血分数保留性心力衰竭是近年来心力衰竭最常见的形式之一。由于其病理生理机制复杂,导致治疗选择有限,且预后不佳。目前,研究者们普遍认为合并症诱发的全身慢性炎症可能是驱动射血分数保留性心力衰竭患者发生左心室不良重塑及舒张功能障碍的关键所在。因此了解这种发病模式潜在的调控机制,有利于探索有效的治疗方法。

Heart failure with preserved ejection fraction(HFpEF)has become one of the most common types of heart failure in recent years.Due to the complex pathophysiological mechanism,the choice of therapy is limited and the prognosis is poor.At present,experts believe that comorbidity-induced systemic chronic inflammation is the primary cause of abnormal left ventricular remodeling and diastolic dysfunction in HFpEF patients.Therefore,understanding the potential regulatory mechanism of this pathogenesis is conducive to explore effective treatments methods.