动脉粥样硬化中自噬与凋亡相互作用的研究进展

Crosstalk Between Autophagy and Apoptosis in Atherosclerosis

动脉粥样硬化是心血管疾病的病理基础,以血管内脂质沉积和斑块形成为特点。凋亡和自噬作为细胞生存的调控者,在动脉粥样硬化中发挥重要作用。近期研究发现凋亡与自噬之间存在复杂的相互作用,通过二者的相互作用可反馈调节自噬或凋亡,进而调节动脉粥样硬化,可能为心血管疾病提供治疗方案。

Atherosclerosis is the pathological basis of cardiovascular diseases and is characterized by intravascular lipid deposition and plaque formation.As regulators of cell survival,apoptosis and autophagy play an important role in atherosclerosis.Recent studies have found a complex crosstalk between apoptosis and autophagy which can feedback regulate autophagy or apoptosis,and then regulate atherosclerosis,further may provide treatment options for cardiovascular diseases.