屈螺酮炔雌醇片联合子宫动脉栓塞在治疗瘢痕妊娠术后子宫功能恢复及安全性评价

The Efficacy and Safety Evaluation of Drospirenone Ethinyl Estradiol Tablets Combined with Uterine Artery Embolization in the Treatment of Uterine Function Recovery after Scar Pregnancy

目的:屈螺酮炔雌醇片联合子宫动脉栓塞在治疗瘢痕妊娠术后子宫功能恢复及安全性评价。方法:选取2018年 9 月—2019 年 9 月河南科技大学第一附属医院收治的 60 例瘢痕妊娠患者,根据住院号采取随机原则分为对照组和观察组,每组各30例。所有患者均行子宫动脉栓塞后行人工流产方式终止妊娠,术后对照组服用戊酸雌二醇,观察组在对照组的基础上加用屈螺酮炔雌醇片,比较两组患者子宫内膜厚度、阴道出血量、出血持续时间、月经复潮时间及药物不良反应的发生率情况。结果:观察组阴道出血持续时间、月经复潮时间及阴道出血量较显著短于对照组患者,差异有统计学意义(t=22.209、36.975、2.249,P<0.05),此外,经过治疗后观察组患者子宫内膜厚度较对照组增厚,差异有统计学意义 (t=3.738,P<0.05)。观察组患者的药物不良反应的发生率与对照组相比,差异无统计学意义 (χ^(2)=0.206,P>0.05)。结论:瘢痕妊娠子宫动脉栓塞后应用屈螺酮炔雌醇片干预可促进子宫内功能的恢复,提高临床子宫修复效果,同时却明显未增加药物不良反应的发生率,值得在临床推广使用。

Objective: To evaluate the uterine function recovery and safety of drospirenone and ethinyl estradiol tablets combined with uterine artery embolization in the treatment of scar pregnancy. Methods: A total of 60 patients with scar pregnancy who were admitted to the hospital from September 2018 to September 2019 were selected and randomly divided into the control group and the observation group according to the hospitalization number, with 30 cases in each group. All patients underwent uterine artery embolization and then underwent artificial abortion to terminate the pregnancy. After the operation, the control group was given estradiol valerate, and the observation group was given drospirenone and ethinyl estradiol tablets on the basis of the control group.The endometrial thickness, vaginal bleeding volume, bleeding duration, menstrual rehydration time and the incidence of adverse drug reactions were compared between the two groups. Results: The duration of vaginal bleeding, menstrual rehydration time and vaginal bleeding volume in the observation group were significantly shorter than those in the control group, and the differences were statistically significant (t=22.209, 36.975, 2.249, P<0.05). After treatment, the endometrial thickness of the observation group was increased compared with that of the control group, and the difference was statistically significant (t=3.738, P<0.05). There was no statistically significant difference in the incidence of adverse drug reactions between the observation group and the control group (χ^(2)=0.206, P>0.05). Conclusion: The application of drospirenone and ethinyl estradiol tablets after uterine artery embolization in scar pregnancy can promote the recovery of intrauterine function and improve the clinical effect of uterine repair, but at the same time, it does not significantly increase the incidence of adverse drug reactions, which is worthy of promotion in the clinical practice.