血清钙在子宫内膜癌患者血清中的表达及意义分析

Expression and significance of serum calcium in serum of patients with endometrial cancer

目的探究血清钙在子宫内膜癌患者血清中的表达及临床意义。方法回顾性选择2019年1—12月辽宁省锦州市中心医院收治的100例子宫内膜癌患者为研究组,另选取同期50例子宫内膜良性病变患者为病例对照组,选取50名体检健康者为对照组,对比3组个体的血清钙及肿瘤标志物糖类抗原12-5(CA12-5)、糖类抗原19-9(CA19-9)水平差异,分析上述指标相关性,绘制血清钙对子宫内膜癌患者诊断ROC曲线,并初步探究不同结局子宫内膜癌患者血清钙水平差异。结果①研究组患者的血清钙水平明显低于病例对照组和对照组,CA12-5和CA19-9水平明显高于病例对照组与对照组(P<0.05);②子宫内膜癌患者血清钙水平同CA12-5和CA19-9水平均呈现明显的负相关性(r=-0.5460,r=-0.5539,P<0.05);③以血清Ca^(2+)水平≥2.32 mmol/L为截断点,绘制血清钙对子宫内膜癌的诊断ROC曲线,计算其AUC为0.7175(95%CI=0.5407~0.8943,P=0.0186);④随访18个月,子宫内膜癌死亡组患者的血清钙水平明显低于存活组,肿瘤标志物水平明显高于存活组(P<0.05)。结论血清钙在子宫内膜癌患者体内呈现明显的异常低表达态,可考虑将其作为子宫内膜癌诊断及预后分析的参考指标应用于临床。

Objective To investigate the expression and clinical significance of serum calcium in the serum of patients with endometrial cancer.Methods A total of 100 patients with endometrial cancer treated in Jinzhou Central Hospital in Liaoning Province from January to December 2019 were retrospectively selected as the study group,and another 50 patients with benign endometrial lesions during the same period were selected as the case-control group,and 50 healthy individuals received physical examination were selected as the control group.The levels of serum calcium and tumor markers carbohydrate antigen 12-5(CA12-5)and carbohydrate antigen 19-9(CA19-9)were compared among the three groups,to analyze the correlation between the above indexes,plot the ROC curve of serum calcium for diagnosis of endometrial cancer,and initially investigate the differences of serum calcium levels among endometrial cancer patients with different outcomes.Results①In the study group,the serum calcium level was significantly lower than those in the case-control group and the control group,and the levels of CA12-5 and CA19-9 were significantly higher than those in the case-control group and the control group(P<0.05).②The serum calcium levels in the patients with endometrial cancer were significantly negatively correlated with the levels of CA12-5 and CA19-9(r=-0.5460,r=-0.5539,P<0.05).③Using the serum Ca^(2+)level≥2.32 mmol/L as the cutoff point,the ROC curve of serum calcium for the diagnosis of endometrial cancer was drawn,and the AUC was calculated as 0.7175(95%CI=0.5407-0.8943,P=0.0186).④At 18 months of follow-up,the serum calcium levels of the patients who died of endometrial cancer were significantly lower than those of the patients who survived,and the tumor marker levels were significantly higher than those of the patients who survived(P<0.05).Conclusion Serum calcium presents a significant abnormally low expression status in patients with endometrial cancer.It can be considered as a reference index in the diagnosis and prognosis analysis of endometrial cancer in clinical practice.