莪术醇抗肿瘤作用机制研究进展

Progress in the study of curcumol’s anti-tumor mechanisms

天然药物是研发新的抗癌药物的一个巨大宝库。莪术醇是从草本植物根茎中提取的倍半萜类纯单体化合物。其抗肿瘤作用通过抑制肿瘤细胞生长、增殖、侵袭迁移,诱导细胞凋亡、周期阻滞,降低肿瘤细胞耐药性等多种途径来实现。还可以制成纳米结构脂质载体和新型衍生物,靶向杀死肿瘤细胞。莪术醇在肿瘤治疗中的多靶点活性表明莪术醇作为抗癌药物的重要性。但仍需要进一步研究其作用机制和临床前实验和临床试验,以挖掘其抗癌潜力。

Natural crude drugs are a huge treasure trove for the research and development of new anticancer drugs.Curcumol is a pure monomeric compound of sesquiterpenoids extracted from the rhizomes of herbaceous plants.Its anti-tumor effect can be achieved by inhibiting the growth,proliferation,invasion and migration of tumor cells,inducing their apoptosis and cycle arrest,and reducing their drug resistance.It can also be made into nanostructured lipid carriers and new derivatives to target and kill tumor cells.Though the multi-targets activity of curcumol in tumor therapies demonstrates its importance as an anticancer drug,it is still necessary to further study its mechanisms of action,to conduct more preclinical and clinical trials in order to fully tap its anticancer potentials.