体位性高血压的诊疗及临床意义研究进展

Research progress in diagnosis and treatment and clinical significance of orthostatic hypertension

体位性高血压是一种被忽视但常见的血压调节异常的临床现象,其定义缺乏共识,病理生理机制尚不明确,可能与自主神经系统功能障碍、交感神经过度活跃有关。越来越多的证据表明体位性高血压与高血压和糖尿病等相关。目前尚无研究证明治疗体位性高血压可以改善预后,但由于体位性高血压在高血压人群中并不少见,且可能与心血管风险增加有关,因此伴或不伴体位性高血压的患者都应该引起重视。本文就近年来体位性高血压的定义、诊断、病理生理学机制、临床意义及治疗最新研究进行论述,期望可为以后的体位性高血压研究提供新思路。

Orthostatic hypertension is a neglected but common clinical phenomenon of abnormal blood pressure regulation.Its pathophysiological mechanism is unclear and may be related to autonomic nervous system dysfunction and sympathetic overactivity.A growing number of studies have shown that orthostatic hypertension is associated with hypertension and diabetes mellitus.Treatment of orthostatic hypertension has not been shown to improve outcomes.However,orthostatic hypertension is not a low percentage of the hypertensive population and may be associated with increased cardiovascular risk,so hypertensive patients with or without orthostatic hypertension should be paid attention to.This paper provides the latest researches on the definition,diagnosis,pathophysiological mechanism,clinical significance,and treatment of orthostatic hypertension in recent years to provide new ideas for future research on orthostatic hypertension.