Tet调控Th17/Treg细胞分化参与自身免疫性疾病发病的研究进展

Tet in regulation of Th17/Treg cell differentiation and in participatesion of pathogenesis of autoimmune diseases

CD4^(+)T细胞是人体免疫重要的一部分,其中辅助性T细胞17(T helper cell 17,Th17)和调节性T细胞(regulatory T cells,Treg)两个新近发现的CD4^(+)T细胞亚群在自身免疫疾病的发生发展中也起关键作用。Th17细胞能够引起自身免疫和炎性反应,而Treg细胞抑制疾病发生并维持免疫稳态;10~11易位蛋白(ten-eleven translocation,Tet)作为DNA去甲基化的关键因子,当其缺失时能够影响Th17/Treg免疫平衡。本文针对Tet调控Th17/Treg细胞分化参与自身免疫疾病发生发展的研究进展作一综述。

CD4^(+)T cells are an important part of human immunity.T helper cell 17(Th17)and regulatory T cells(Treg),two newly discovered subsets of CD4^(+)T cells,play a key role in the occurrence and development of autoimmune diseases.Th17 cause autoimmunity and inflammation,while Treg inhibit the emergence of diseases and maintain immune homeostasis.Ten-eleven translocation(Tet),as a key factor in DNA demethylation,affects the Th17/Treg balance and involves in the progression of autoimmune diseases when it is absent.This review focuses on the research of the regulatory role of Tet on Th17/Treg cell immunization balance and the possible pathogenesis of autoimmune diseases.