脑小血管病性认知障碍血液学标志物的研究进展

Research progress on hematological markers of cognitive impairment in patients with cerebral small vessel disease

如今,血管性认知障碍(vessel cognitive impairment,VCI)已成为痴呆的第2大病因,其中脑小血管病(cerebral small vessel disease,CSVD)被公认为VCI最常见的病因。临床实践中,脑小血管病认知功能障碍(CSVCI)的诊断主要通过神经量表评估、神经影像学等检查,并排除其他疾病导致认知功能障碍后得出诊断。近年来,因血液学标志物检测技术愈加成熟。众多学者认为,血液学标志物检测是一种简便、实用的检测手段,为CSVCI的临床诊断提供重要的参考价值,以此早期对CSVCI进行干预。本文主要对近10年CSVCI血液学标志物的研究进展作一综述。

Nowadays,vessel cognitive impairment(VCI)has become the second leading cause of dementia,and cerebral small vessel disease(CSVD)is recognized as the most common cause of VCI.In clinical practice,the diagnosis of cognitive impairment of cerebrovascular disease(CSVCI)is mainly based on the evaluation of neurological scale and neuroimaging,and the diagnosis is obtained after excluding cognitive impairment caused by other diseases.In recent years,due to the increasingly mature detection technology of hematological markers,many scholars believe that hematological marker detection is a simple and practical detection method,and provides important references for the clinical diagnosis of CSVCI,so as to intervene CSVCI in the early stage.This paper reviews the research progress of CSVCI hematological markers in recent 10 years.