嘧菌酯/聚丙烯腈微球的制备及缓释性能

Preparation and release properties of azoxystrobin/polyacrylonitrile microspheres

采用聚丙烯腈(PAN)为原料,通过静电喷雾技术制备了载有嘧菌酯的PAN微球。研究了工作电压、嘧菌酯与PAN质量比对微球形貌与性能的影响,并通过释放试验评价了载药微球的缓释性能。结果表明:静电纺丝机的工作电压是控制微球粒径大小的主要因素,其粒径随电压增大而减小,最小可至0.86μm,而嘧菌酯与PAN的质量比则主要影响微球的载药量与包封率,微球载药量最高可达34.53%,包封率最高可达79.78%。此外,载药微球在3种不同pH的缓冲溶液中均实现了长达400 min的稳定释放,表明其具有出色的缓释性能。在静电纺丝机工作电压15 kV、工作距离20 cm、PAN溶液质量浓度2%、m(嘧菌酯):m(PAN)=1:2及进样速率1.25 mL/h的条件下,可制备具有良好形貌与缓释性能的嘧菌酯/PAN微球,本研究可为农药减量增效提供一种技术路径。

In this study,polyacrylonitrile(PAN)was used to prepare PAN microspheres loaded with azoxystrobin by electrostatic spraying technology.The effects of working voltage and mass ratio of azoxystrobin and PAN on the morphology and properties of microspheres were investigated.The sustained-release properties of the drug-loaded microspheres were evaluated by release tests.The results show that the working voltage of the electrospinning machine is the main factor controlling the particle size of the microspheres.The particle size decreases with the increase of the voltage and the minimum size can reach 0.86μm.While the mass ratio of azoxystrobin and PAN mainly affected the loading capacity and encapsulation efficiency of the microspheres.The loading capacity of the microspheres can reach up to 34.53%,and the encapsulation efficiency can reach up to 79.78%.In addition,the drugloaded microsphere achieved stable release for up to 400 min in three buffer solutions with different pH,indicating its excellent sustained-release performance.Collectively,under the condition that the working voltage of the electrospinning machine is 15 kV,the working distance is 20 cm,the mass concentration of PAN solution is 2%,m(azoxystrobin):m(PAN)=1:2 and the injection speed is 1.25 mL/h,the prepared azoxystrobin/PAN microspheres exhibited good morphology and sustainedrelease properties.This study provides a technical approach for pesticide reduction and efficiency enhancement.