女贞子化学成分、药理作用及药动学研究进展

Research Progress on Chemical Constituents,Pharmacological Effects and Pharmacokinetics of Ligustri Lucidi Fructus

女贞子系木犀科(Oleaceae)女贞属植物女贞(Ligustrum lucidum)的干燥果实,为我国传统中药,具有滋补肝肾、明目乌发的功效。女贞子含三萜类、环烯醚萜类、苯乙醇苷类及黄酮类等多种化学成分。许多药理作用研究表明女贞子具有抗肿瘤、抗氧化、抗炎镇痛、保肝、抗骨质疏松、免疫调节、降血糖降血脂、抗菌抗病毒等活性。对女贞子的化学成分、药理作用及药代动力学研究进行综述,以期为我国女贞子资源的进一步开发和利用提供参考。

Ligustri Lucidi Fructus is the dried fruits of Ligustrum lucidum,belonging to Oleaceae,which is a traditional Chinese medicine with the effects on nourishing liver and kidney,improving eyesight and hair-blacking.Ligustri Lucidi Fructus contains triterpenoids,iridoids,phenylethanoid glycosides and flavonoids,etc.Many pharmacological studies had shown that it has anti-tumor,antioxidant,anti-inflammatory and analgesic,hepato-protective,antiosteoporosis,immunomodulatory,hypoglycemic and hypolipidemic,antibacterial and antiviral activities.The chemical constituents,pharmacological effects and pharmacokinetics of Ligustri Lucidi Fructus were reviewed,which would provide reference for further development and utilization of Ligustri Lucidi Fructus in China.