枸橼酸莫沙必利对反流性食管炎患者的治疗效果

Effect of Mosapride Citrate on the Treatment and Intervention of Reflux Esophagitis

目的探究枸橼酸莫沙必利对反流性食管炎患者的治疗效果。方法将沈阳七三九医院收治反流性食管炎患者86例纳入本研究,随机分为对照组(43例)和研究组(43例),对照组采用奥美拉唑治疗,研究组采用枸橼酸莫沙必利治疗,对比两组的治疗效果。结果在治疗前,观察组与对照组的TNF-α、CRP、IL-6水平比较无显著差异(P>0.05);在治疗后,观察组TNF-α、CRP、IL-6水平均低于对照组(P<0.05)。研究组患者MOT、GAS水平分别为(202.04±12.08)pg/mL、(34.26±2.04)pg/mL,与对照组的(202.07±12.11)pg/mL、(34.24±2.07)pg/mL对比,差异无统计学意义(P>0.05);治疗后,研究组患者MOT、GAS水平分别为(249.16±13.01)pg/mL、(46.22±2.75)pg/mL,均显著高于对照组的(210.53±14.67)pg/mL、(40.26±2.47)pg/mL,差异有统计学意义(P<0.05)。与对照组治疗总有效率相比,观察组的治疗总有效率更高(72.09%vs.97.67%,P<0.05)。研究组患者烧心、胸痛、反流症状消失时间分别为(3.04±0.58)、(3.06±0.62)、(4.05±0.98)d,均显著短于对照组的(5.16±1.13)、(5.87±1.04)、(7.94±1.24)d,差异有统计学意义(P<0.05)。结论枸橼酸莫沙必利治疗反流性食管炎患者的临床效果显著,有助于改善患者的炎症情况,缩短患者的症状恢复时间,提升预后效果。

Objective To explore the effect of mosapride citrate in the treatment and intervention of reflux esophagitis.Methods A total of 86 patients with reflux esophagitis treated in our hospital from February 2018 to February 2019 were selected as the research subjects,eighty-six patients with reflux esophagitis admitted to Shenyang Qisanjiu Hospital were included in this study and were randomly divided into control group(43 cases)and study group(43 cases).The control group was treated with omeprazole,and the study group was treated with mosapride citrate.The therapeutic effects of the two groups were compared.Results Before treatment,there was no significant difference in the levels of TNF-α,CRP and IL-6 between the observation group and the control group(P>0.05);after treatment,the levels of TNF-α,CRP and IL-6 in the observation group were lower than those in the control group group(P<0.05).The levels of MOT and GAS in the study group were(202.04±12.08)pg/mL and(34.26±2.04)pg/mL,respectively,compared with(202.07±12.11)pg/mL and(34.24±2.07)pg/mL in the control group,there was no significant difference(P>0.05);after treatment,the levels of MOT and GAS in the study group were(249.16±13.01)pg/mL and(46.22±2.75)pg/mL,which were significantly higher than those in the control group(210.53±14.67)pg/mL,(40.26±2.47)pg/mL,the difference was statistically significant(P<0.05).Compared with the total effective rate of the control group,the total effective rate of the observation group was higher(72.09%vs.97.67%,P<0.05).The disappearance times of heartburn,chest pain and reflux symptoms in the study group were(3.04±0.58),(3.06±0.62),and(4.05±0.98)days,respectively,which were significantly shorter than those in the control group(5.16±1.13)and(5.87±1.04),(7.94±1.24)d,the difference was statistically significant(P<0.05).Conclusion The clinical effect of mosapride citrate in the treatment of patients with reflux esophagitis is significant,which helps to improve the inflammation of patients,shorten the recovery time of patients'symptoms,and improve the prognosis.