丁苯酞联合重组人组织型纤溶酶原激活物治疗急性脑梗死患者的临床效果

Clinical Effect of Butylphthalide Combined with rt-PA in the Treatment of Acute Cerebral Infarction

目的探讨在重组人组织型纤溶酶原激活物(rt-PA)治疗基础上联合丁苯酞对急性脑梗死患者病情控制及恢复的影响。方法选择150例急性脑梗死患者,均给予rt-PA静脉溶栓治疗,将其中75例归为观察组,联合丁苯酞软胶囊口服,比较两组患者的神经功能、生活活动能力、血清细胞因子、生活质量差异。结果观察组治疗7 d、治疗14 d时的NIHSS评分分别降至(8.67±1.02)分与(5.23±0.49)分,显著低于对照组的(12.24±1.55)、(9.17±0.86)分,差异有统计学意义(P<0.05);观察组治疗7 d、治疗14 d时ADL评分分别升至(77.41±6.13)分与(96.10±4.13)分,显著高于对照组的(56.31±5.99)、(82.48±6.38)分,差异有统计学意义(P<0.05);治疗后,观察组hs-CRP、IL-6、HGF水平分别为(2.76±0.89)mg/L、(3.54±1.76)pg/L、(245.18±29.43)pg/L,均显著低于对照组的(8.05±1.30)mg/L、(16.27±2.18)pg/L、(525.46±63.07)pg/L,差异有统计学意义(P<0.05);观察组治疗后的生命活力、生理功能、情感职能、社会功能、精神健康、总体健康评分均显著高于对照组,差异有统计学意义(P<0.05)。结论在常规溶栓治疗基础上联合丁苯酞药物可对急性脑梗死患者神经功能恢复及生活能力恢复起到积极的影响。

Objective To study the effect of rt-PA treatment combined with butylphthalide on the control and recovery of patients with acute cerebral infarction.Methods A total of 150 patients with acute cerebral infarction were selected and all of them were given rt-PA intravenous thrombolytic therapy.Seventy-five of them were included in the observation group and oral administration of soft capsules of butylphthalide.Differences in nerve function,life activity,serum cytokines and quality of life were compared between the two groups.Results The NIHSS score in the observation group decreased to(8.67±1.02)and(5.23±0.49)points at 7 days and 14 days respectively,which was significantly lower than(12.24±1.55)and(9.17±0.86)in the control group,the differences were statistically significant(P<0.05).The ADL score in the observation group increased to(77.41±6.13)and(96.10±4.13)at 7 days and 14 days respectively,which was significantly higher than(56.31±5.99),(82.48±6.38)in the control group,the differences were statistically significant(P<0.05).After treatment,hs-CRP,IL-6 and HGF levels in the observation group were(2.76±0.89)mg/L,(3.54±1.76)pg/L and(245.18±29.43)pg/L,respectively,which were significantly lower than(8.05±1.30)mg/L,(16.27±2.18)pg/L and(525.46±63.07)pg/L in the control group,the differences were statistically significant(P<0.05).After treatment,the scores of life vitality,physiological function,emotional function,social function,mental health and overall health in the observation group were significantly higher than those in the control group,the differences were statistically significant(P<0.05).Conclusion On the basis of conventional thrombolytic therapy combined with butylphthalide can have a positive effect on the recovery of nerve function and living ability of patients.