绝经后女性血清骨转换标志物与骨密度相关性的研究

Relationships between bone mineral density and serum bone turnover markers in postmenopausal women

目的筛选能反映绝经后女性骨质丢失情况的血清骨转换标志物(BTMs)。方法选取2020年1月至2021年10月在浙江省人民医院体检的绝经后女性225例作为研究对象,对225例绝经后女性进行血清BTMs[包括1型胶原交联羧基端肽(CTX)、1型原胶原氨基端前肽(P1NP)、骨钙素(OC)]和骨密度(BMD)[包括股骨颈BMD(FNBMD)、全髋部BMD(THBMD)和L_(1~4)BMD(LSBMD)]检测,然后分析血清BTMs之间、血清BTMs与BMD之间的相关性。结果绝经后女性3个血清BTMs之间均呈中度正相关(均P<0.01),其中血清CTX、OC与FNBMD、THBMD、LSBMD均呈负相关(均P<0.05)。结论在绝经后女性中,可优先选择血清CTX和OC来反映其骨质丢失情况,帮助预测骨折风险。

Objective To screen the serum bone turnover markers(BTMs)reflecting bone loss in postmenopausal women.Methods A total of 225 postmenopausal women who underwent physical examination in Zhejiang Provincial People's Hospital from January 2020 to October 2021 were recruited.Serum BTMs[including carboxy-terminal cross-linked telopeptide of type 1 collagen(CTX),procollagen type 1 N-terminal propeptide(P1NP)and osteocalcin(OC)]and bone mineral density(BMD)[including femoral neck BMD(FNBMD),total hip BMD(THBMD)and lumbar spine BMD(LSBMD)]were measured in 225 postmenopausal women.Then the correlation between serum BTMs and BMD was analyzed.Results There were moderate positive correlations among 3 serum BTMs in postmenopausal women(all P<0.01),and there were negative correlations between serum CTX,OC and FNBMD,THBMD and LSBMD(all P<0.05).Conclusion Serum CTX and OC are preferred to reflect bone loss and help predict fracture risk In postmenopausal women.