针灸联合甲氨蝶呤在基层医院治疗早期类风湿关节炎的疗效观察

Clinical effect of acupuncture therapy combined with Methotrexate tablets in the treatment of early rheumatoid arthritis

目的探讨针灸联合甲氨蝶呤治疗早期类风湿关节炎的疗效。方法选择2017年12月—2019年12月在北京市延庆区医院接受治疗的90例类风湿关节炎患者,随机分为对照组(n=45,采用甲氨蝶呤治疗),治疗组(n=45,采用甲氨蝶呤联合针灸治疗),观察2组临床疗效、关节活动情况、类风湿因子、C反应蛋白和不良反应情况。结果治疗组患者临床缓解率为71.11%,明显高于对照组的51.11%(P<0.05)。治疗前,2组患者DAS28评分差异无统计学意义(P>0.05);治疗后,治疗组DAS28评分明显低于对照组(P<0.05)。治疗组类风湿因子、C反应蛋白等指标情况均显著优于对照组(P<0.05)。2组不良反应发生率差异无统计学意义(P>0.05)。结论针灸联合甲氨蝶呤治疗早期类风湿关节炎患者,可提升其关节活动度,安全性性高,值得推广。

Objective To observe the clinical efficacy of acupuncture therapy combined with methotrexate tablets in the treatment of early rheumatoid arthritis(RA).Methods A total of 90 patients with RA were randomly divided into control group with 45 cases and treatment group with 45 cases.Control group received methotrexate 10mg per time,once a week.Treatment group received acupuncture therapy,on the basis of control group.The clinical efficacy,disease activity score 28(DAS28),and the incidence of adverse reactions were compared between 2 groups.Results After treatment,the total effective rates of two groups were 51.11%and 71.11%with significant difference(P<0.05),DAS28 score in treatment group was lower than that in control group(P<0.05),the main indexes of treatment group RF、CRP are better than control group.Conclusion Acupuncture therapy combined with methotrexate tablets have a definitive clinical efficacy in the treatment of patients with early RA,which can significantly relieve the clinical symptoms of patients and is worthy of clinical application.