血清同型半胱氨酸、叶酸及维生素B12在子痫前期病人中的表达及其相关性分析

Expression and correlation analysis of serum homocysteine,folic acid and vitamin B12 in patients with preeclampsia

目的:探讨血清同型半胱氨酸(Hcy)、叶酸(FA)、维生素B12(VitB12)在子痫前期病人中的表达及其与子痫前期(PE)疾病严重程度的相关性。方法:选取60例子痫前期病人作为观察组,根据疾病严重程度不同分为重度PE组(n=30)和PE组(n=30);另选取同期行产前检查的30名妊娠妇女作为健康对照组。比较3组血清Hcy、FA、VitB12水平;分析重度PE组与PE组病人Hcy、FA、VitB12异常率;分析PE组病人Hcy、FA、VitB12水平的相关性及Hcy、FA、VitB12水平与PE疾病严重程度和围产儿结局的相关性。结果:重度PE组、PE组病人Hcy水平均高于健康对照组(P<0.05),FA和VitB12水平均低于健康对照组(P<0.05);重度PE组病人Hcy水平高于PE组(P<0.05),FA和VitB12水平均低于PE组(P<0.05)。重度PE组病人Hcy、FA异常率均低于PE组(P<0.05和P<0.01),2组VitB12异常率差异无统计学意义(P>0.05)。Spearman等级相关分析结果显示,PE组病人Hcy水平与FA水平呈负相关关系(P<0.05),FA水平与VitB12水平呈正相关关系(P<0.05),Hcy水平与VitB12水平无明显相关关系(P>0.05);Hcy水平与子痫前期疾病严重程度呈正相关关系(P<0.05),FA水平与子痫前期疾病严重程度呈负相关关系(P<0.05),VitB12水平与子痫前期疾病严重程度无明显相关关系(P>0.05);Hcy水平与Apgar评分呈负相关关系(P<0.05),FA水平与Apgar评分呈正相关关系(P<0.05),VitB12水平与Apgar评分无明显相关关系(P>0.05)。结论:子痫前期病人病情越严重,血清Hcy水平越高,FA水平越低。FA与VitB12水平呈正相关关系,FA与Hcy水平呈负相关关系。

Objective:To investigate the expressions of serum homocysteine(Hcy),folic acid(FA)and vitamin B12(VitB12)in patients with preeclampsia and their correlation with the severity of preeclampsia.Methods:Sixty patients with preeclampsia were selected as the observation group,and divided into severe PE group(n=30)and PE group(n=30)according to the severity of the disease,and 30 pregnant women for prenatal checkups at the same period were set as the healthy control group.The serum levels of Hcy,FA and VitB12 in the three groups were compared.The abnormal rates of Hcy,FA and VitB12 in the severe PE group and PE group were analyzed.The correlation of Hcy,FA and VitB12 levels in PE group,and the correlation of Hcy,FA and VitB12 levels with the severity of PE disease and perinatal outcome were analyzed.Results:The level of Hcy in the severe PE group and PE group was higher than that in the healthy control group(P<0.05),and the level of FA and VitB12 was lower than that in the healthy control group(P<0.05).The level of Hcy in the severe PE group was higher than that in the PE group(P<0.05),and the level of FA and VitB12 was lower than that in the PE group(P<0.05).The abnormal rate of Hcy and FA in the severe PE group was lower than that in the PE group(P<0.05 and P<0.01),and there was no significant difference in the abnormal rate of VitB12 between the two groups(P>0.05).The results of Spearman rank correlation analysis showed that the level of Hcy was negatively correlated with the level of FA(P<0.05),the level of FA was positively correlated with the level of VitB12 in the PE group(P<0.05),and the level of Hcy was not significantly correlated with the level of VitB12(P>0.05);the level of Hcy was positively correlated with the severity of preeclampsia disease(P<0.05),the level of FA was negatively correlated with the severity of preeclampsia disease(P<0.05),and the level of VitB12 was not significantly correlated with the severity of preeclampsia disease(P>0.05);the level of Hcy was negatively correlated with the Apgar score(P<0.05),the level of FA was positively correlated with the Apgar score(P<0.05),and the level of VitB12 was not significantly correlated with the Apgar score(P>0.05).Conclusions:The serum level of Hcy is higher,and the level of FA is lower with the accelerating severity of preeclampsia.There is a positive correlation between FA level and VitB12 level,and a negative correlation between FA level and Hcy level.