点阵CO_(2)激光联合超分子水杨酸治疗原发性皮肤淀粉样变

Successful Treatment of Primary Cutaneous Amyloidosis by Fractional CO_(2) Laser Combined with Supramolecular Salicylic Acid

目的:原发性皮肤淀粉样变现有的治疗方案中,没有一种是可以确保有效或疗效足够令人满意的金标准,临床亟待探求疗效良好且副作用小的理想治疗方法。方法:对2例原发性皮肤淀粉样变患者予点阵CO_(2)激光联合30%超分子水杨酸治疗2个疗程。结果:2例患者在治疗2个疗程后中均表现出良好的临床效果,在治疗后1个月内皮肤逐渐修复,3个月内随访无明显不良反应及复发情况。结论:点阵CO_(2)激光联合超分子水杨酸可能是治疗原发性皮肤淀粉样变的一种有效方法,值得对其远期疗效及机制行进一步的临床研究。

Objective Among the available therapeutic options for primary cutaneous amyloidosis,none of them is the gold standard which can ensure the eff ective or satisfactory curative eff ect.It is urgent to explore the ideal treatment method with good curative eff ect and little side eff ect in clinic.Methods Two patients with primary cutaneous amyloidosis were treated with fractional CO_(2) laser combined with 30%supramolecular salicylic acid for 2 courses.Results Two patients showed good clinical response after 2 courses of treatment.Their skin was repaired gradually within 1 month after treatment,and there was no obvious adverse reaction and recurrence within 3 months of follow-up.Conclusion Fractional CO_(2) laser combined with supramolecular salicylic acid may be an eff ective method for the treatment of primary cutaneous amyloidosis,and its long-term eff ect and mechanism are worthy of further clinical study.