瑞舒伐他汀和阿托伐他汀对冠心病患者的调脂、非调脂作用及对动脉粥样硬化的逆转作用

Effects of rosuvastatin and atorvastatin on lipid regulation,non lipid regulation and reversal of atherosclerosis in patients with coronary heart disease

目的探讨冠心病患者采用瑞舒伐他汀和阿托伐他汀治疗的调脂、非调脂作用及对动脉粥样硬化的逆转效果。方法56例冠心病患者,依据随机数字表法分成A组与B组,各28例。A组给予瑞舒伐他汀片治疗,B组给予阿托伐他汀治疗。对比两组治疗前后血脂水平、颈动脉内膜中层厚度(IMT)、同型半胱氨酸(Hcy)及超敏C反应蛋白(hs-CRP)。结果治疗后,两组高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)、总胆固醇(TC)水平优于治疗前,且A组TC(3.99±0.47)mmol/L、TG(1.46±0.10)mmol/L、LDL-C(1.92±0.36)mmol/L均低于B组的(4.75±0.41)、(1.60±0.16)、(2.38±0.39)mmol/L,HDL-C(1.82±0.16)mmol/L高于B组的(1.18±0.12)mmol/L,差异有统计学意义(P<0.05)。治疗后,两组颈动脉IMT、Hcy、hs-CRP均优于治疗前,且A组颈动脉IMT(0.91±0.17)mm、Hcy(9.80±1.16)μmol/L、hs-CRP(4.09±1.03)mg/L均低于B组的(1.45±0.12)mm、(12.02±9.68)μmol/L、(9.27±1.04)mg/L,差异有统计学意义(P<0.05)。结论冠心病患者采用阿托伐他汀和瑞舒伐他汀治疗,都有降低Hcy水平、血hs-CRP及改善血脂水平的效果,因而有助于逆转动脉粥样硬化,但瑞舒伐他汀的效果优于阿托伐他汀。

Objective To discuss the effects of rosuvastatin and atorvastatin on lipid regulation,non lipid regulation and reversal of atherosclerosis in patients with coronary heart disease.Methods A total of 56patients with coronary heart disease were divided into group A and group B according to the random numerical table,with 28 cases in each group.Group A was treated with rosuvastatin tablets,and group B was treated with atorvastatin.Both groups were compared in terms of blood lipid levels,carotid intima-media thickness(IMT),homocysteine(Hcy)and high-sensitivity C-reactive protein(hs-CRP)before and after treatment.Results After treatment,the levels of high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),triglyceride(TG),and total cholesterol(TC)in the two groups were better than those before treatment in this group;the TC(3.99±0.47)mmol/L,TG(1.46±0.10)mmol/L,and LDL-C(1.92±0.36)mmol/L in group A were lower than(4.75±0.41),(1.60±0.16),and(2.38±0.39)mmol/L in group B,and the HDL-C(1.82±0.16)mmol/L was higher than(1.18±0.12)mmol/L in group B;all the differences were statistically significant(P<0.05).After treatment,the carotid artery IMT,Hcy and hs-CRP in both groups were better than those before treatment in this group;the carotid artery IMT(0.91±0.17)mm,Hcy(9.80±1.16)μmol/L,and hs-CRP(4.09±1.03)g/L in group A were lower than(1.45±0.12)mm,(12.02±9.68)μmol/L,and(9.27±1.04)g/L in group B;all the differences were statistically significant(P<0.05).Conclusion Both atorvastatin and rosuvastatin can reduce the level of Hcy,hs-CRP and improve the level of blood lipid in patients with coronary heart disease,which is helpful to reverse atherosclerosis,but the effect of rosuvastatin is better than that of atorvastatin.