术前小剂量米非司酮对腹腔镜子宫肌瘤剔除术的影响

Effect of preoperative low-dose mifepristone on laparoscopic myomectomy

目的分析术前小剂量米非司酮对腹腔镜子宫肌瘤剔除术的影响。方法50例子宫肌瘤患者,采用随机数字表法分为对照组和观察组,每组25例。对照组患者采用常规腹腔镜子宫肌瘤剔除术,观察组患者术前给予小剂量米非司酮治疗后行腹腔镜子宫肌瘤剔除术。比较两组患者相关临床指标、手术指标、术后出血情况。结果治疗后,两组患者子宫肌瘤体积、子宫体积均小于治疗前,血红蛋白水平高于治疗前,且观察组子宫肌瘤体积、子宫体积小于对照组,血红蛋白水平高于对照组,差异具有统计学意义(P<0.05)。观察组术中出血量(56.43±4.12)ml少于对照组的(87.19±5.12)ml,差异有统计学意义(P<0.05);观察组手术时间(78.43±4.12)min短于对照组的(87.19±11.12)min,差异有统计学意义(P<0.05)。观察组术后阴道出血时间(9.14±2.78)d短于对照组的(11.27±2.12)d,差异有统计学意义(P<0.05);观察组阴道出血发生率4.00%(1/25)低于对照组的28.00%(7/25),差异有统计学意义(P<0.05)。结论术前应用小剂量米非司酮对腹腔镜子宫肌瘤剔除术的影响较大,可有效改善患者临床症状,促进手术顺利完成,减少出血量,改善预后,值得推广。

Objective To analyze the effect of preoperative low-dose mifepristone on laparoscopic myomectomy.Methods A total of 50 patients with hysteromyoma were divided into control group and observation group by random numerical table,with 25 cases in each group.Patients in the control group were treated with conventional laparoscopic myomectomy,and patients in the observation group were treated with low-dose mifepristone before surgery and then laparoscopic myomectomy.The clinical indicators,surgical indicators and postoperative bleeding were compared between the two groups.Results After treatment,the myoma size and uterine volume in the two groups were less than those before treatment in this group,and the level of hemoglobin was higher than that before treatment in this group;the improvement of myoma size,uterine volume in the observation group were less than those in the control group,and hemoglobin level was higher than that in the control group;all the differences were statistically significant(P<0.05).The intraoperative blood loss(56.43±4.12)ml in the observation group was less than(87.19±5.12)ml in the control group,and the difference was statistically significant(P<0.05).The operation time(78.43±4.12)min of the observation group was shorter than(87.19±11.12)min of the control group,and the difference was statistically significant(P<0.05).The postoperative vaginal bleeding time(9.14±2.78)d in the observation group was shorter than(11.27±2.12)d in the control group,and the difference was statistically significant(P<0.05).The incidence of vaginal bleeding 4.00%(1/25)in the observation group was lower than 28.00%(7/25)in the control group,and the difference was statistically significant(P<0.05).Conclusion Application of low-dose mifepristone before surgery has a great influence on laparoscopic myomectomy,which can effectively improve the clinical symptoms of patients,promote the smooth completion of the operation,reduce bleeding and improve the prognosis.It is worthy of promotion.