益生菌联合牙周基础疗法治疗慢性牙周炎的疗效观察

Observation on the efficacy of probiotics combined with basic periodontal therapy on the treatment of chronic periodontitis

目的探究益生菌联合牙周基础疗法治疗慢性牙周炎的临床疗效。方法100例慢性牙周炎患者随机分为实验组和对照组,各50例。对照组采用牙周基础疗法进行治疗,实验组采用牙周基础疗法联合益生菌治疗。比较两组治疗前后牙周探诊深度(PPD)、出血指数(BI)、白介素-6(IL-6)、白介素-10(IL-10)、基质金属蛋白酶-9(MMP-9)水平及口腔内菌群存在情况。结果治疗后,实验组PPD、BI水平分别为(2.46±0.75)mm、(1.52±0.52),均显著低于对照组的(3.56±0.81)mm、(2.18±0.67),差异均有统计学意义(P<0.05)。治疗后,实验组口腔内聚合梭杆菌、福赛坦菌、中间普氏菌、牙龈卟啉单胞菌、伴放线菌放线杆菌存在率均低于对照组,差异均有统计学意义(P<0.05)。治疗后,实验组IL-6、IL-10、MMP-9水平分别为(6.46±2.75)、(10.99±1.32)、(18.02±2.52)pg/ml,均显著优于对照组的(7.76±2.91)、(9.28±1.37)、(20.46±2.48)pg/ml,差异均有统计学意义(P<0.05)。结论益生菌联合牙周基础治疗慢性牙周炎患者的临床疗效显著优于单纯采用牙周基础疗法治疗,可阻止病菌的生长与繁殖,具有临床推广价值。

Objective To investigate the clinical efficacy of probiotics combined with basic periodontal therapy on the treatment of chronic periodontitis.Methods A total of 100 patients with chronic periodontitis were randomly divided into experimental group and control group,with 50 cases in each group.The control group was treated with basic periodontal therapy,while the experimental group was treated with basic periodontal therapy combined with probiotics.Comparison was made on periodontal pocket probing depth(PPD),gingival bleeding index(BI),interleukin-6(IL-6),interleukin-10(IL-10)and matrix metalloproteinase-9(MMP-9)levels before and after treatment,and oral flora between the two groups.Results After treatment,the levels of PPD and BI in the experimental group were(2.46±0.75)mm and(1.52±0.52),which were significantly lower than(3.56±0.81)mm and(2.18±0.67)in the control group,and the differences were statistically significant(P<0.05).After treatment,the proportion of fusobacterium nucleatum,tannerella forsythia,prevotella intermedia,porphyromonas gingivalis,and actinobacillus actinomycetemcomitans in the experimental group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of IL-6,IL-10 and MMP-9 in the experimental group were(6.46±2.75),(10.99±1.32),and(18.02±2.52)pg/ml,which were significantly better than(7.76±2.91),(9.28±1.37),and(20.46±2.48)pg/ml in the control group,and the differences were statistically significant(P<0.05).Conclusion Probiotics combined with basic periodontal therapy has better clinical efficacy than basic periodontal therapy alone for the treatment of chronic periodontitis.It can prevent the growth and reproduction of bacteria and is valuable for promotion.