瑞舒伐他汀与辛伐他汀对老年高脂血症的改善效果对比

Comparison of the effect of rosuvastatin and simvastatin on the improvement of hyperlipidemia in the elderly

目的探讨瑞舒伐他汀与辛伐他汀对老年高脂血症的改善效果。方法100例老年高脂血症患者,按照治疗药物不同分为对照组(49例)和观察组(51例)。对照组患者采用辛伐他汀治疗,观察组患者采用瑞舒伐他汀治疗。比较两组患者治疗前后血脂[总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、甘油三酯(TG)]水平,不良反应发生情况,治疗前后生活质量评分。结果治疗前,两组TC、LDL-C、HDL-C、TG水平比较差异无统计学意义(P>0.05);治疗后,两组TC、LDL-C、HDL-C、TG水平均低于治疗前,且观察组TC(2.45±0.12)mmol/L、LDL-C(2.45±0.12)mmol/L、HDL-C(1.38±0.25)mmol/L、TG(1.89±0.40)mmol/L低于对照组的(4.56±0.52)、(2.56±0.29)、(1.56±0.25)、(2.29±0.46)mmol/L,差异有统计学意义(P<0.05)。两组不良反应发生率对比差异无统计学意义(P>0.05)。治疗前,对照组和观察组的生活质量评分分别为(54.36±5.69)、(54.21±4.85)分,组间比较差异无统计学意义(P>0.05)。治疗后,对照组和观察组的生活质量评分分别为(76.16±7.14)、(83.72±4.06)分;两组的生活质量评分均高于治疗前,且观察组生活质量评分高于对照组,差异有统计学意义(P<0.05)。结论老年高脂血症患者采用瑞舒伐他汀与辛伐他汀治疗均具有良好的效果,而瑞舒伐他汀在改善患者高血脂方面疗效更佳,安全性高。

Objective To discuss the effect of rosuvastatin and simvastatin on the improvement of hyperlipidemia in the elderly.Methods A total of 100 elderly patients with hyperlipidemia were divided into control group(49 cases)and observation group(51 cases)according to the different treatment drugs.Patients in the control group were treated with simvastatin,and patients in the observation group were treated with rosuvastatin.Both groups were compared in terms of levels of blood lipids[total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),triglycerides(TG)],and the quality of life scores before and after treatment,and occurrence of adverse reactions.Results Before treatment,there was no statistically significant difference in the levels of TC,LDL-C,HDL-C and TG between the two groups(P>0.05).After treatment,the levels of TC,LDL-C,HDL-C and TG in the two groups were lower than those before treatment in this group,and the TC(2.45±0.12)mmol/L,LDL-C(2.45±0.12)mmol/L,HDL-C(1.38±0.25)mmol/L and TG(1.89±0.40)mmol/L in the observation group were lower than(4.56±0.52),(2.56±0.29),(1.56±0.25),and(2.29±0.46)mmol/L in the control group.All the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Before treatment,the quality of life scores of the control group and the observation group were(54.36±5.69)and(54.21±4.85)points,and the difference was not statistically significant(P>0.05).After treatment,the quality of life scores of the control group and the observation group were(76.16±7.14)and(83.72±4.06)points,respectively;the quality of life scores of the two groups were higher than those of this group before treatment,and the quality of life scores of the observation group were higher than those of the control group.All the differences were statistically significant(P<0.05).Conclusion Both rosuvastatin and simvastatin have good application effect in the treatment of elderly patients with hyperlipidemia,and resulvastatin is more effective and safe in improving hyperlipidemia in patients.