替硝唑与地塞米松、根管治疗联用对牙周-牙髓联合病变患者的临床疗效分析

Clinical efficacy analysis of tinidazole combined with dexamethasone and root canal therapy in patients with combined periodontic-endodontic lesion

目的探讨在牙周-牙髓联合病变患者治疗中采用替硝唑+地塞米松+根管治疗方案的临床疗效。方法76例牙周-牙髓联合病变患者,采用随机数字表法分为对照组及观察组,每组38例。对照组应用甲醛甲酚+根管治疗,观察组应用替硝唑+地塞米松+根管治疗。对比两组治疗前后的临床疗效指标[牙周探诊深度(PD)、龈沟出血指数(SBI)、菌斑指数(PLI)、牙龈指数(GI)]及血清炎症因子[肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)、白细胞介素-1β(IL-1β)]水平、不良反应发生情况。结果治疗后,观察组患者的PD、SBI、PLI、GI分别为(3.06±0.85)mm、(1.46±0.65)分、(0.72±0.36)分、(0.91±0.31)分,均低于对照组的(3.85±0.86)mm、(2.03±0.85)分、(1.21±0.39)分、(1.69±0.51)分,差异具有统计学意义(P<0.05)。治疗后,观察组患者的TNF-α、hs-CRP、IL-1β水平分别为(6.03±1.05)ng/L、(7.21±1.06)mg/L、(4.13±1.02)ng/L,均低于对照组的(7.30±1.18)ng/L、(9.25±1.50)mg/L、(5.26±1.18)ng/L,差异具有统计学意义(P<0.05)。两组不良反应发生率对比,差异无统计学意义(P>0.05)。结论牙周-牙髓联合病变患者采取替硝唑+地塞米松+根管治疗方案的临床疗效满意,可有效降低血清炎症因子水平,且安全性良好。

Objective To discuss the clinical efficacy of tinidazole combined with dexamethasone and root canal therapy in patients with combined periodontic-endodontic lesion.Methods A total of 76 patients with combined periodontal-endodontic lesions were randomly divided into control group and observation group by random numerical table,with 38 cases in each group.The control group received formaldehyde cresol combiend with root canal therapy,while the observation group received tinidazole combined with dexamethasone and root canal therapy.Both groups were compared in terms of clinical efficacy indicators[periodontal probing depth(PD),gingival sulcus bleeding index(SBI),plaque index(PLI),gingival index(GI)]and serum inflammatory factors[tumor necrosis factor-α(TNF-α),high-sensitivity C-reactive protein(hs-CRP),interleukin-1β(IL-1β)]levels before and after treatment,and the occurrence of adverse reactions.Results After treatment,the PD,SBI,PLI and GI of the observation group were(3.06±0.85)mm,(1.46±0.65)points,(0.72±0.36)points,and(0.91±0.31)points,which were lower than(3.85±0.86)mm,(2.03±0.85)points,(1.21±0.39)points,and(1.69±0.51)points of the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of TNF-α,hs-CRP,and IL-1βin the observation group were(6.03±1.05)ng/L,(7.21±1.06)mg/L,and(4.13±1.02)ng/L,which were lower than(7.30±1.18)ng/L,(9.25±1.50)mg/L,and(5.26±1.18)ng/L in the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Tinidazole combined with dexamethasone and root canal therapy shows satisfactory clinical efficacy on patients with combined periodontic-endodontic lesion,and can effectively lower the level of serum inflammatory factors with high safety.