双相障碍患者伴自杀风险的相关因素及与甲状腺功能水平关系分析

Analysis of Suicide Risks Related Factors and the Relationship with Thyroid Function in Patients with Bipolar Disorder

目的:探讨双相障碍患者伴自杀风险的相关因素并分析患者自杀风险与甲状腺功能水平间的关系。方法:回顾性分析2020年3月-2021年10月在泉州市第三医院进行诊治的双相障碍患者121例,收集患者资料,伴自杀风险组69例,不伴自杀风险组52例,分析患者伴自杀风险的相关因素及与甲状腺功能水平关系。结果:伴自杀风险患者与不伴自杀风险患者性别、年龄、首次起病年龄、病程、汉密尔顿焦虑量表(HAMA)评分、汉密尔顿抑郁量表(HAMD)评分、杨氏躁狂评定量表(YMRS)评分、生物节律、发病周期性、不典型抑郁、精神症状及目前服药比较差异均无统计学意义(P>0.05)。伴自杀风险组有家族史、有焦虑症状、发病前有诱因占比高于不伴自杀风险组,差异有统计学意义(P<0.05)。多因素Logistic回归分析结果显示有焦虑症状、发病前有诱因为双相障碍患者伴自杀风险的危险因素(P<0.05)。伴自杀风险组与不伴自杀风险组FT;、TSH水平比较差异无统计学意义(P>0.05),伴自杀风险组FT;水平高于不伴危险组,差异有统计学意义(P<0.05)。FT;、TSH与双相障碍患者伴自杀风险无相关性(P>0.05),FT;与双相障碍患者伴自杀风险有相关性(P<0.05)。结论:双相障碍患者伴自杀风险的相关因素包括焦虑症状及发病前有诱因,且与FT;水平存在相关性。

Objective:To explore the related factors of suicide risks in patients with bipolar disorder and analyze the relationship between risks of suicide and thyroid function.Method:A retrospective analysis was performed on 121 patients with bipolar disorder diagnosed and treated in Quanzhou Third Hospital from March 2020 to October 2021.Data of patients were collected,including 69 patients in the suicide risk group and 52 patients in the non-suicide risk group.The correlation factors of patients with suicide risk and thyroid function level were analyzed.Result:There were no significant differences in gender,age,age of first onset,course of disease,Hamilton anxiety scale (HAMA) score,Hamilton depression scale (HAMD) score,Young manic rating scale (YMRS) score,circadian rhythm,periodicity,atypical depression,psychiatric symptoms and whether to take drugs between the suicide risk group and non-suicide risk group (P>0.05).The proportion of family history,anxiety symptoms,inducement before onset in the suicide risk group with were higher than those in the non-suicide risk group (P<0.05).Multivariate Logistic regression analysis showed that patients with anxiety symptoms,predisposing factors were the risk factors of bipolar disorder with suicide risk (P<0.05).There were no significant differences in the levels of FT;and TSH between the suicide risk group and non-suicide risk group (P>0.05).The level of FT;in the suicide risk group was higher than that in the non-suicide risk group (P<0.05).There were no correlation between FT;and TSH and suicide risk in patients with bipolar disorder (P>0.05),but there was correlation between FT;and suicide risk in patients with bipolar disorder (P<0.05).Conclusion:Suicide risk in patients with bipolar disorder include anxiety symptoms and predisposing factors before onset,which is correlated with the level of FT;.