安宫牛黄丸辅助治疗卒中相关性肺炎的临床观察

Clinical observation of Angong Niuhuang Pill adjuvant treatment for stroke-associated pneumonia

目的探讨安宫牛黄丸对卒中相关性肺炎患者的治疗效果。方法纳入2020年1月至2021年2月河南省商丘市第一医院呼吸重症科、神经内科住院的卒中后相关性肺炎患者80例,采取随机数字法分为治疗组、对照组各40例。两组患者均给予抗炎、化痰、痰液引流等常规治疗,治疗组在此基础上加用安宫牛黄丸。比较两组治疗后的体温下降时间、临床疗效、血白细胞计数(WBC)、C反应蛋白(CRP)、降钙素原(PCT)、白介素-6(IL-6)的变化。结果治疗7 d后,治疗组有效率(90.0%)明显高于对照组(72.5%),差异有统计学意义(P<0.05)。治疗组患者炎症指标(WBC、CRP、PCT、IL-6)均较对照组明显下降,差异有统计学意义(P<0.05)。结论安宫牛黄丸辅助治疗卒中相关性肺炎临床效果确切,值得临床推广应用。

Objective To investigate the therapeutic effect of Angong Niuhuang Pill on patients with stroke-associated pneumonia(SAP).Methods A total of 80 patients with SAP treated in the respiratory intensive care unit(RICU)or nerve ward in our hospital from January 2020 to February 2021 were included.They were divided into treatment group and control group by random number method.There were 40 cases in each group.The control group were treated with routine treatment,while the treatment group were treated with not only routine treatment but also Angong Niuhuang Pill.The changes of inflammatory factors including WBC,CRP,PCT,and IL-6 between the two groups were compared after treatment.Results After one week of treatment,the effective rate of the treatment group was higher than that of the control group(90.0%vs.72.5%,P<0.05).The levels of inflammatory indexes(WBC,CRP,PCT and IL-6)in treatment group were significantly lower than those in the control group(P<0.05).Conclusion The efficacy of Angong Niuhuang Pill is significant in the treatment of SAP,which is worth being popularized.