新型含氟嘧啶硫醚类化合物的合成及杀虫活性研究

Synthesis and Insecticidal Activity of Novel Fluoropyrimidine Thioethers

为了开发新型的具有杀虫活性化合物,本研究设计并合成了一系列含氟嘧啶硫醚类化合物,结构经过^(1)H NMR和^(13)C NMR进行表征,并采用浸叶法对其生物活性进行了测定。结果表明,目标化合物的产率为52%~88%,均对小菜蛾表现出一定的杀虫活性,其中化合物3m的活性最好,在质量浓度为1 mg/L时,对小菜蛾的致死率为97%。本试验为含氟嘧啶硫醚类杀虫剂的合成提供新的思路。

In order to develop new compounds with insecticidal activity,a series of fluoropyrimidine thioethers compounds were designed and synthesized.The chemical structures of target compounds were characterized by ^(1)H NMR and ^(13)C NMR and insecticidal activity was tested by leaf immersion method.The results showed that the yield of all of the new compounds were 52%-88%,and had certain control activity against Plutella xylostella,and when the mass concentration was 1 mg/L,the lethal rate of compound 3m to Plutella xylostella was 97%.The finding could provide a new idea for the synthesis of fluoropyrimidine thioethers compounds.