CD47分子相关信号通路及CD47在病原感染中的研究进展

Research Progress of CD47-Related Signaling Pathway and the Role of CD47 in Pathogenic Infection

CD47是一种广泛表达于细胞表面的跨膜糖蛋白,是细胞逃逸固有免疫监视的重要检查点之一。其参与调控的信号通路以及表达水平的改变在免疫调节、病原感染以及抗肿瘤免疫中发挥的重要作用也逐步被人们所认识。本文从CD47的结构与生物学特性,CD47与配体整合素、凝血栓蛋白1以及信号调节蛋白结合所作用的信号转导过程,病原体感染促进宿主CD47表达及CD47在不同感染免疫应答的作用这三个方面进行了文献综述,并对未来CD47靶向免疫治疗在感染相关肿瘤中的应用前景进行了展望,为今后的研究提供一定参考。

CD47,a transmembrane glycoprotein widely expressed on the cell surface,is one of the important checkpoints through which cells escape innate immune surveillance.The important role of CD47-related signaling pathway and changes in expression level in immune regulation,pathogen infection and anti-tumor immunity has gradually come to be recognized.We reviewed herein the structure and biological characteristics of CD47,the interaction and the downstream signaling of CD47 with integrin,thrombospondin 1,and signal regulatory protein,and the upregulated expression of CD47 induced by the infection of different pathogens and the role of CD47 in different types of immune response to infection.Discussions were made regarding the prospective application of CD47 targeted immunotherapy in pathogenic infection-related cancers,intending to provide guidance for future research.