嗜酸性粒细胞凋亡在变应性鼻炎发病机制中的作用研究

The role of eosinophil apoptosis in the pathogenesis of allergic rhinitis

嗜酸性粒细胞(EOS)在哮喘和其他变态反应性疾病的发病过程中是重要的效应细胞。在变应性炎症过程中,对凋亡细胞的凋亡和胞吐作用的药理作用的研究,为炎症性气道疾病的治疗提供了新的见解,尤其是以嗜酸性粒细胞为主的气道炎症。这两种方法可用于治疗干预,允许成功操控炎症解决,并减少与现有治疗相关的不良反应。因此,通过控制EOS凋亡来调控变应性炎症,目前并且未来可能是过敏性疾病的主要治疗关注点。

Eosinophils are important effector cells in the pathogenesis of asthma and other allergic diseases.In the process of allergic inflammation,the research on the pharmacological effects of apoptosis and exocytosis of apoptotic cells provides new insights for the treatment of inflammatory airway diseases,especially airway inflammation mainly composed of eosinophils.These two approaches can be used for therapeutic interventions that allow successful manipulation of inflammation resolution and reduce adverse reactions associated with existing treatments.Therefore,controlling eosinophil apoptosis to regulate allergic inflammation is the main therapeutic target of allergic diseases at present and in the future.