血清PCT、CRP在下呼吸道细菌感染诊断中的价值及检出率评价

The Value and Detection Rate of Serum PCT and CRP in the Diagnosis of Lower Respiratory Tract Bacterial Infection

目的对血清PCT、CRP在下呼吸道细菌感染诊断中的价值及检出率展开系统分析。方法选取2020年4月—2021年4月该院治疗的60例疑似下呼吸道细菌感染患者作为研究对象,依据是否被细菌感染分为观察1组(细菌感染,n=30)及观察2组(未被细菌感染,n=30),同期选取30名健康体检者纳入对照组,分别检测3组血清PCT(降钙素原)、CRP(C-反应蛋白)水平,观察1组与观察2组血清PCT、CRP检测结果,血清PCT、CRP指标检测的灵敏度、特异度、阳性预测值以及阴性预测值。结果观察1组血清PCT(0.52±0.26)μg/L、CRP水平(36.20±19.28)mg/L,观察2组血清PCT(0.49±0.22)μg/L,CRP水平(30.16±18.44)mg/L,对照组血清PCT(0.38±0.15)μg/L,CRP水平(2.26±2.08)mg/L,观察1组PCT和CRP水平高于观察2组,但差异无统计学意义(t=0.428、1.240,P=0.631、0.220)。观察1组PCT和CRP水平高于对照组,差异有统计学意义(t=2.555、9.586,P<0.05)。观察2组PCT和CRP水平高于对照组,差异有统计学意义(t=2.263、8.235,P<0.05)。观察1组相比观察2组血清PCT、CRP水平阳性率较高,差异有统计学意义(P<0.05);单一(PCT、CRP)指标检测相较于联合指标(PCT+CRP)检测灵敏度、特异度、阳性预测值及阴性预测值均较低,差异有统计学意义(P<0.05)。结论血清PCT、CRP水平升高提示下呼吸道细菌感染,血清PCT、CRP指标联合检测的灵敏度、特异度、阳性预测值及阴性预测值高,建议在临床中借鉴、推广。

Objective To systematically analyze the value and detection rate of serum PCT and CRP in the diagnosis of lower respiratory tract bacterial infection.Methods Sixty patients with suspected lower respiratory tract bacterial infection treated from April 2020 to April 2021 were selected as the study subjects.According to whether they were infected by bacteria,they were divided into observation group 1(bacterial infection,n=30).And observation 2 groups(not infected with bacteria,n=30).During the same period,30 healthy subjects were selected and included in the control group.Serum PCT(procalcitonin)and CRP(C-reactive protein)levels were detected in the 3 groups respectively,and the detection results of serum PCT and CRP in group 1 and group 2 were observed,and the sensitivity,specificity,and positivity of serum PCT and CRP indicators Predictive value and negative predictive value.Results Serum PCT(0.52±0.26)μg/L and CRP levels(36.20±19.28)mg/L in the observe group 1,serum PCT(0.49±0.22)μg/L and CRP levels(30.16±18.44)mg/L in the observe group 2,control group had serum PCT(0.38±0.15)μg/L and CRP levels(2.26±2.08)mg/L,the PCT and CRP levels of observe group 1 were higher than observed group 2,but the difference was not statistically significant(t=0.428,1.240,P=0.631,0.220);the PCT and CRP levels in observe group 1 were higher than in the control group, the difference was statistically significant (t=2.555,9.586, P<0.05);the PCT and CRP levels in the observe group 2 were higher than the control groups, the difference was statistically significant (t=2.263,8.235, P<0.05). The positive rates of serum PCT and CRP levels in observation group 1 were higher than those in observation group 2, and the difference was statistically significant (P<0.05);The sensitivity, specificity, positive predictive value and negative predictive value of single index (PCT,CRP) were lower than those of combined index (PCT + CRP), and the difference was statistically significant (P<0.05). Conclusion the elevated levels of serum PCT and CRP indicate bacterial infection of the lower respiratory tract. The combined detection of serum PCT and CRP has high sensitivity, specificity, positive predictive value and negative predictive value. It is recommended to use it for reference and promotion in clinical practice.