胰岛素泵短期强化方案在初诊2型糖尿病患者中的应用研究

Application of Short-term Intensive Insulin Pump Regimen in Newly Diagnosed Patients with Type 2 Diabetes Mellitus

目的探讨胰岛素泵短期强化方案在初诊2型糖尿病患者中的应用效果。方法选择2019年1月—2020年12月商河县人民医院收治的150例初诊2型糖尿病患者,以随机数表法划分为两组。对照组75例采取常规胰岛素皮下注射治疗,研究组75例应用胰岛素泵短期强化治疗。比较两组治疗前后血糖、胰岛功能[胰岛β细胞指数(HOMA-β)与胰岛素抵抗指数(HOMA-IR)]与炎症因子[超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)与肿瘤坏死因子-α(TNF-α)]的变化。同时,针对两组不良反应进行观察与记录。结果治疗后,研究组糖化血红蛋白(6.65±1.03)%、空腹血糖(5.67±1.00)mmol/L、餐后2 h血糖(7.68±1.02)mmol/L较对照组(7.82±1.25)%、(6.82±1.02)mmol/L、(8.62±1.27)mmol/L低,差异有统计学意义(t=6.256、6.972、4.998,P<0.05)。治疗后,研究组HOMA-IR(2.80±0.20)较对照组(4.30±0.52)低,HOMA-β(80.32±14.65)较对照组(64.04±12.74)高,差异有统计学意义(t=23.316、7.262,P<0.05)。治疗后,研究组IL-6(12.52±3.89)pg/L、hs-CRP(12.65±3.45)mg/L、TNF-α(21.46±4.08)mg/L较对照组(20.47±2.79)pg/L、(17.65±3.03)mg/L、(26.85±3.55)mg/L低,差异有统计学意义(t=14.382、9.430、8.631,P<0.05)。研究组不良反应发生率(0.00%)与对照组(2.67%)对比,差异无统计学意义(χ^(2)=0.507,P>0.05)。结论胰岛素泵短期强化方案能够有效调节初诊2型糖尿病患者的血糖与胰岛功能,抑制炎症反应,适于临床推广。

Objective To investigate the effect of short-term intensive insulin pump regimen in newly diagnosed patients with type 2 diabetes mellitus.Methods A total of 150 newly diagnosed type 2 diabetes patients admitted to Shanghe County People's Hospital from January 2019 to December 2020 were selected and divided into two groups by random number table method.75 patients in the control group were treated with subcutaneous injection of conventional insulin,and 75 patients in the study group were treated with short-term intensive insulin pump therapy.The blood glucose,islet function[islet beta cell index(HOMA-β)and insulin resistance index(HOMA-IR)]and inflammatory factors[high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)]changes.At the same time,the adverse reactions of the two groups were observed and recorded.Results After treatment,the glycated hemoglobin in the study group was(6.65±1.03)%,fasting blood glucose(5.67±1.00)mmol/L,and postprandial 2 h blood glucose(7.68±1.02)mmol/L,compared with the control group(7.82±1.25)%,(6.82±1.02)mmol/L,(8.62±1.27)mmol/L was lower,and the difference was statistically significant(t=6.256,6.972,4.998,P<0.05).After treatment,HOMA-IR in the study group(2.80±0.20)was lower than that in the control group(4.30±0.52),and HOMA-β(80.32±14.65)was higher than that in the control group(64.04±12.74),and the difference was statistically significant(t=23.316,7.262,P<0.05).After treatment,IL-6(12.52±3.89)pg/L,hs-CRP(12.65±3.45)mg/L,TNF-α(21.46±4.08)mg/L in the study group were lower than that of the control group(20.47±2.79)pg/L,(17.65±3.03)mg/L,(26.85±3.55)mg/L,the difference was statistically significant(t=14.382,9.430,8.631,P<0.05).There was no statistically significant difference in the incidence of adverse reactions in the study group of 0.00%compared with 2.67%of the control group(χ^(2)=0.507,P>0.05).Conclusion The short-term intensive insulin pump program can effectively regulate the blood glucose and islet function of newly diagnosed type 2 diabetes patients,and inhibit the inflammatory response,which is suitable for clinical promotion.