口腔癌根治术+改良颈淋巴结清扫术治疗口腔癌的效果分析

Analysis of the Effect of Radical Resection of Oral Cancer+Modified Neck Dissection in the Treatment of Oral Cancer

目的探讨口腔癌根治术+改良颈淋巴结清扫术治疗口腔癌的临床效果。方法选取2017年6月—2018年6月该院收治的72例口腔癌患者为研究对象,按照不同手术方法将其分为对照组(n=36)和研究组(n=36),对照组予以口腔癌根治术治疗,研究组采用口腔癌根治术+改良颈淋巴结清扫术治疗,比较两组手术指标、视觉模拟评分法(VAS)评分、生活质量评分、术后3年转移率及生存率。结果两组术中出血量以及手术时间比较[(194.07±12.19)mL vs(189.25±11.76)mL]、[(99.28±11.35)min vs(97.71±11.84)min],差异无统计学意义(t=1.707、0.574,P>0.05);研究组术后1、3个月的VAS评分明显低于对照组[(4.12±0.54)分vs(5.64±0.71)分]、[(2.03±0.41)分vs(2.97±0.25)分],差异有统计学意义(t=10.224、11.745,P<0.05);两组术前面容外形、消遣娱乐、活动能力等生活质量评分比较,差异无统计学意义(P>0.05),研究组术后各项生活质量评分均明显低于对照组,差异有统计学意义(P<0.05);研究组术后3年转移率低于对照组(13.89%vs 36.11%),术后3年生存率高于对照组(80.56%vs 41.67%),差异有统计学意义(χ^(2)=4.741、11.455,P<0.05)。结论临床治疗口腔癌的过程中,采用口腔癌根治术+改良颈淋巴结清扫术的联合治疗方案,有助于提高患者术后生活质量和生存率,且不会增加手术风险。

Objective To investigate the clinical effect of radical resection of oral cancer+modified neck dissection in the treatment of oral cancer.Methods A total of 72 patients with oral cancer who were admitted to the hospital from June 2017 to June 2018 were selected as the research objects,and they were divided into the control group(n=36)and the study group(n=36)according to different surgical methods.The control group was treated with radical surgery for oral cancer,while the study group was treated with radical surgery for oral cancer+modified neck dissection.The surgical indicators,visual analogue scale(VAS)score,quality of life score,3-year postoperative metastasis rate and survival rate were compared between the two groups.Results There was no statistically significant difference in intraoperative blood loss and operation time between the two groups[(194.07±12.19)mL vs(189.25±11.76)mL]、[(99.28±11.35)min vs(97.71±11.84)min],(t=1.707,0.574,P>0.05).The VAS scores of the study group at 1 month and 3 months after the operation were significantly lower than those of the control group[(4.12±0.54)points vs(5.64±0.71)points]、[(2.03±0.41)points vs(2.97±0.25)points],the differences was statistical significance(t=10.224,11.745,P<0.05).There was no statistically significant difference in the scores of quality of life such as preoperative appearance, recreation, and activity ability between the two groups(P>0.05). The postoperative quality of life scores in the study group were significantly lower than those in the control group, the difference was statistically significant(P<0.05). The 3-year metastasis rate in the study group was lower than that in the control group (13.89% vs 36.11%), and the 3-year survival rate in the study group was higher than that in the control group (80.56% vs 41.67%), the difference was statistically significant (χ^(2)=4.741,11.455,P<0.05). Conclusion In the process of clinical treatment of oral cancer, the combined treatment plan of radical resection of oral cancer and modified neck dissection is adopted. It helps to improve the quality of life and survival rate of patients after surgery without increasing the risk of surgery.