肠道微生态平衡监测对妊娠高血压疾病的诊断价值

Diagnostic value of intestinal microeclogic balance monitoring in pregnancy-induced-hypertension

妊娠高血压疾病是孕产妇和婴儿病死率增高的主要原因。然而临床上对于该类疾病的病因和发病机制并不十分清楚,除了评估孕妇血压水平、蛋白尿、器官受累程度及胎儿情况之外,缺乏有效的实验室预防、监测及诊疗手段。而肠道菌群作为人体最大的微生态系统,相关研究成果已在各类疾病中显现出巨大的临床潜在价值。相比之下,肠道菌群与妊娠高血压疾病的研究相对滞后。由于孕妇体质、代谢等状况的特殊性,疾病与肠道菌群变换叠加的病理过程更为复杂。目前,相关研究虽有报道,但在两者相互关系、致病机制等方面分析并不完整、全面。本文对肠道微生态与妊娠高血压疾病的多项研究结果进行综述,并分析了妊娠高血压疾病的研究现状以及相关实验室监测指标的应用价值,探讨了肠道菌群作为妊娠高血压疾病新型标志物的可行性,为临床上对妊娠高血压疾病的诊断提供了新思路。

Pregnancy-induced-hypertension(PIH)is a leading cause of mortality rate increase in pregnant women and infants.However,the etiology and pathogenesis of PIH is still unclear in clinic.Beside of evaluating the blood pressure level,proteinuria,degree of organ involvement and fetal condition,there is a lack of the effective means of laboratory prevention,monitoring and diagnosis and treatment.The intestinal microbiota serve as the largest micro-ecosystem in the human body,the related study results show the enormous clinical potential values in various diseases.However,the researches on the relationship between intestinal microbiota and PIH are relatively lagging behind.Due to the particularity of pregnant women status such as the body constitution,metabolism,which makes the pathological process of disease and intestinal microbiota change superposition more complex.At present,although the related studies have reported,but the analysis on their relationship and pathogenesis is not complete and comprehensive.This paper reviews the multiple studies results of intestinal microbiota and PIH,analyze the study status quo of PIH and application value of related laboratory monitoring indicators,investigate the feasibility of intestinal microbiota as the new type marker of PIH,and provide a new ideal for the diagnosis of PIH in clinic.