血清P-选择素与冠心病合并高血压患者PCI术后不良事件发生的相关性研究

Correlation between Serum P-selectin and Adverse Events after PCI in Patients with Coronary Heart Disease and Hypertension

目的分析P-选择素与冠心病合并高血压患者PCI术后不良事件发生的相关性。方法研究对象选取2019年3月—2020年3月在临朐县人民医院心内科收治的经PCI手术的冠心病合并高血压患者80例,在出院后1年检测P-选择素水平,按P-选择素水平分为A组46例(<50.00μg/L)和B组34例(≥50.00μg/L),比较两组收缩压、舒张压、低密度脂蛋白(LDL-C)、超敏C反应蛋白(hs-CRP)、不良事件发生率和发生时间。分析P-选择素与血压、主要心脏不良事件(MACE)发生的相关性。结果B组患者的收缩压、舒张压及hs-CRP均明显高于A组,而LDL-C明显低于A组,差异有统计学意义(P<0.05)。A组MACE发生率及MACE发生时间均显著优于B组,差异有统计学意义(P<0.05)。相关相关性分析显示,P-选择素水平与患者PCI术后血压及MACE发生均呈正相关(r=0.365、0.285、0.336,P<0.001)。结论P-选择素水平与冠心病合并高血压患者PCI术后血压及MACE发生率呈正相关,检测P-选择素水平可能有助于预测患者MACE发生风险。

Objective To analyze the correlation between P-selectin and adverse events after PCI in patients with coronary heart disease and hypertension.Methods 80 patients with coronary heart disease and hypertension who underwent PCI surgery in the Department of Cardiology of Linqu County People's Hospital from March 2019 to March 2020 were selected.The level of P-selectin was detected 1 year after discharge.According to the level of P-selectin,46 cases in group A(<50.00μg/L)and 34 cases in group B(≥50.00μg/L)were divided.The systolic blood pressure,diastolic blood pressure,low-density lipoprotein(LDL-C)and high-sensitivity C-reactive protein(hs-CRP),the incidence and time of adverse events were compared between the two groups.The correlation of P-selectin with blood pressure and major adverse cardiac events(MACE)was analyzed.Results The systolic blood pressure,diastolic blood pressure and hs-CRP of group B were significantly higher than those of group A,while LDL-C was significantly lower than that of group A,the difference was statistically significant(P<0.05).The incidence of MACE and the occurrence time of MACE in group A were significantly better than those in group B,the difference was statistically significant(P<0.05).Correlation analysis showed that the level of P-selectin was positively correlated with blood pressure and MACE after PCI(r=0.365,0.285,0.336,P<0.001).Conclusion The level of P-selectin is positively correlated with blood pressure and the incidence of MACE after PCI in patients with coronary heart disease and hypertension.Detection of P-selectin level may help predict the risk of MACE in patients.