二甲双胍联合西格列汀对糖尿病患者血糖控制及胰岛功能的影响

Effects of Metformin Combined with Sitagliptin on Blood Glucose Control and Islet Function in Patients with Diabetes

目的探讨二甲双胍联合西格列汀对糖尿病患者血糖控制及胰岛功能的影响。方法选择2019年10月—2021年10月医院收治的糖尿病患者110例,随机数字抽签分为对照组和观察组,各55例。对照组采取二甲双胍治疗,观察组采取二甲双胍联合西格列汀治疗,测定治疗前后两组患者血糖、糖化血红蛋白及胰岛功能指标水平,观察用药不良反应发生情况。结果 治疗后,两组FBG、2 hBG、HbA1c显著降低,观察组显著低于对照组,差异有统计学意义(P<0.05)。治疗后,两组Homa-IR显著降低,FINS、Homa-β显著提高,而且观察组Homa-IR显著低于对照组,FINS、Homa-β显著高于对照组,差异有统计学意义(P<0.05)。观察组不良反应率5.45%与对照组7.27%比较,差异无统计学意义(P>0.05)。结论 治疗糖尿病采取二甲双胍联合西格列汀用药方案可进一步控制血糖、糖化血红蛋白及血脂水平,改善胰岛功能,而且联合用药不良反应少,安全性好,值得推广。

Objective To investigate the effect of metformin combined with sitagliptin on blood glucose control and islet function in patients with diabetes.Methods A total of 110 diabetic patients admitted to the hospital from October 2019 to October 2021 were selected as the research data.They were randomly divided into the control group and the observation group,with 55 cases in each group.The control group was treated with metformin,and the observation group was treated with metformin combined with sitagliptin.The levels of blood glucose,glycosylated hemoglobin and pancreatic islet function indexes were measured before and after treatment,and the occurrence of adverse drug reactions was observed.Results After treatment,FBG,2 hBG and HbA1c in the two groups were significantly decreased,and the observation group was significantly lower than the control group,the difference was statistically significant(P<0.05).After treatment,Homa-IR in two groups was significantly decreased,FINS and Homa-β were significantly increased,and Homa-IR in observation group was significantly lower than that in control group,while FINS and Homa-β were significantly higher than those in control group,the difference was statistically significant(P <0.05).The adverse reaction rate in the observation group was 5.45% compared with 7.27% in the control group,the difference was not statistically significant(P>0.05).Conclusions Metformin combined with sitagliptin in the treatment of diabetes can further control blood glucose,glycosylated hemoglobin and blood lipid levels,improve islet function,and the combination has fewer adverse reactions and good safety,which is worthy of promotion.