分析舒肝宁与多烯磷脂酰胆碱联合治疗药物性肝损害疾病的效果

Analysis of the Effect of Shuganning Combined with Polyene Phosphatidylcholine in the Treatment of Drug-induced Liver Damage Diseases

目的 评析药物性肝损害疾病患者应用舒肝宁与多烯磷脂酰胆碱联合治疗的效果。方法 选择该院2020年9月—2021年9月接诊的82例药物性肝损害疾病患者为研究对象,根据随机数表法进行分组,每组41例。对照组提供多烯磷脂酰胆碱治疗,观察组提供舒肝宁与多烯磷脂酰胆碱联合治疗,比较两组患者的治疗效果。结果 观察组治疗总有效率(95.12%)高于对照组(68.29%),差异有统计学意义(χ^(2)=9.872,P=0.001)。观察组不良反应(恶心、呕吐、胃部不适、皮疹)发生率(7.32%)小于对照组(31.71%),差异有统计学意义(χ^(2)=7.765,P=0.005)。治疗后,观察组谷丙转氨酶(ALT)(38.56±3.56)U/L、总胆红素(TBIL)(11.52±2.11)μmol/L、谷草转氨酶(AST)(41.56±5.69)U/L、直接胆红素(DBIL)(31.52±2.89)U/L、碱性磷酸酶(ALP)(65.65±7.85)μmol/L水平,均低于对照组(82.66±8.59)U/L、(22.12±4.21)μmol/L、(81.56±8.79)U/L、(44.63±5.28)U/L、(96.63±8.75)μmol/L,差异有统计学意义(P<0.05)。结论 药物性肝损害疾病患者应用舒肝宁与多烯磷脂酰胆碱联合治疗的效果显著,有利于增进疗效,改善患者的不良反应,降低肝功能指标,值得在临床中予以推广。

Objective To evaluate the effect of combined treatment of Shuganning and polyene phosphatidylcholine in patients with drug-induced liver damage.Methods A total of 82 patients with drug-induced liver damage who were admitted to the hospital from September 2020 to September 2021 were selected as the research objects.Grouped according to random number table method,41 cases in each group.The control group was provided with polyene phosphatidylcholine treatment,and the observation group was provided with combined treatment of Shuganning and polyene phosphatidylcholine.The therapeutic effects of the two groups of patients with drug-induced liver damage were compared.Results The total effective rate(95.12%) of the observation group was higher than that of the control group(68.29%),the difference was statistically significant(χ^(2)=9.872,P=0.001).The incidence of adverse reactions(nausea,vomiting,stomach discomfort,rash) in the observation group(7.32%) was lower than that in the control group(31.71%),the difference was statistically significant(χ^(2)=7.765,P=0.005).After treatment,the levels of alanine aminotransferase(ALT)(38.56±3.56) U/L,total bilirubin(TBIL)(11.52±2.11) μmol/L,aspartate aminotransferase(AST)(41.56±5.69) U/L,direct bilirubin(DBIL)(31.52±2.89) U/L,alkaline phosphatase(ALP)(65.65±7.85) μmol/L in the observation group were lower than the control group(82.66±8.59) U/L,(22.12±4.21) μmol/L,(81.56±8.79) U/L,(44.63±5.28) U/L,(96.63±8.75) μmol/L,the difference was statistically significant(P<0.05).Conclusion The combined treatment of Shuganning and polyene phosphatidylcholine in patients with drug-induced liver damage has a significant effect,which is beneficial to improve the curative effect,improve the adverse reactions of patients,and reduce liver function indexes,which is worthy of promotion in clinical practice.