甲状腺功能异常与胆石病相关发病机制

The Pathogenesis of Abnormal Thyroid Function and Cholelithiasis

胆石病发病率随年龄增长、体质量增加而升高,是当今世界重要的公共卫生问题。胆固醇类胆结石(cholesterol gallstone disease,CGD)占胆石病的90%。基于广泛研究提出的CGD的发病机制包括:遗传因素和胆结石易感基因(LITH基因)、胆汁胆固醇过饱和、胆囊运动障碍和肠道因素。甲状腺疾病为内分泌系统的常见疾病,已有一些研究表明甲状腺功能异常与胆石病存在关联。研究甲状腺功能与胆石病发病机制之间的相关性为胆石病的防治提供新思路,使胆石病患者获益。

The incidence of cholelithiasis increases with age and weight gain,which is an important public health problem in the world today.Cholesterol gallstone disease(CGD) accounts for 90% of cholelithiasis.The proposed pathogenesis of CGD based on extensive research includes:genetic factors and the gallstone susceptibility gene(LITH gene),bile cholesterol supersaturation,gallbladder motility disorders,and intestinal factors.Thyroid disease is a common disease of the endocrine system,and some studies have shown that thyroid dysfunction is associated with cholelithiasis.Studying the correlation between thyroid function and the pathogenesis of cholelithiasis provides new ideas for the prevention and treatment of cholelithiasis and benefits patients with cholelithiasis.