血清肿瘤标志物与血液炎症指标联合检测在非小细胞肺癌中的价值

The Value of Serum Tumor Markers Combined with Blood Inflammation Indicators in Non-small Cell Lung Cancer

目的研究血清肿瘤标志物与血液炎症指标联合检测在非小细胞肺癌中的价值。方法选取2016年1月—2021年9月该院收治的非小细胞肺癌患者146例为研究组,根据疾病类型分为肺鳞癌组(n=40)与肺腺癌组(n=106),同时选取146名健康者为对照组。对各组血清癌胚抗原(CEA)、鳞状上皮细胞癌抗原(SCC)、糖类抗原-199(CA-199)、糖类抗原-125(CA-125)、细胞角质蛋白19片段(CYFRA21-1)、中性粒细胞(NEU)、淋巴细胞(LYM)、中性粒细胞与淋巴细胞比值(NLR)进行检测,并对检测结果予以统计学分析。结果研究组CEA、SCC、CA-199、CA-125、CYFRA21-1水平分别为(2.56±0.84)ng/mL、(0.91±0.28)ng/mL、(7.34±2.36)U/mL、(7.06±2.65)U/mL、(3.32±1.42)ng/mL,显著高于对照组,差异有统计学意义(t=19.325、57.126、14.462、7.858、15.712,P<0.05)。研究组NEU、LYM、NLR分别为(5.44±2.34)×10^(9)/L、(1.28±0.51)×10^(9)/L、(5.41±4.35)显著高于对照组,差异有统计学意义(t=10.270、7.294、6.126,P<0.05)。肺鳞癌组CEA水平为(1.55±0.70)ng/mL,SCC水平为(0.92±0.26)ng/mL,CA-199水平为(6.03±7.95)U/mL,CA-125水平为(6.30±1.73)U/mL,CYFRA21-1水平为(3.02±1.55)ng/mL,肺腺癌组CEA水平为(2.58±0.72)ng/mL,SCC水平为(0.80±0.23)ng/mL,CA-199水平为(7.64±2.36)U/mL,CA-125水平为(7.82±2.11)U/mL,CYFRA21-1水平为(3.38±1.21)ng/mL,肺鳞癌组CEA、CA-199、CA-125水平明显低于肺腺癌组,SCC水平明显高于肺腺癌组,差异有统计学意义(t=7.767、2.711、3.845、4.067,P<0.05),两组CYFRA21-1水平对比差异无统计学意义(P>0.05)。肺鳞癌组NEU水平为(5.65±2.69)×10^(9)/L、LYM水平为(1.20±0.50)×10^(9)/L、NLR为(6.13±5.20),肺腺癌组NEU水平为(5.22±2.18)×10^(9)/L、LYM水平为(1.35±0.50)×10^(9)/L、NLR为(4.69±3.40),两组对比差异无统计学意义(t=0.995、1.617、1.955,P>0.05)。结论血清肿瘤标志物与血液炎症指标联合检测在非小细胞肺癌中的价值非常高,值得临床推广应用。

Objective To study the value of serum tumor markers combined with blood inflammatory indicators in non-small cell lung cancer.Methods 146 patients with non-small cell lung cancer admitted to the hospital from January 2016 to September 2021 were selected as the study group.They were divided into lung squamous cell carcinoma group(n=40)and lung adenocarcinoma group(n=106)according to the type of disease.At the same time,146 healthy people were selected as the control group.Serum carcinoembryonic antigen(CEA),squamous cell carcinoma antigen(SCC),carbohydrate antigen-199(CA-199),carbohydrate antigen-125(CA-125),cytokeratin 19 fragment(CYFRA21-1,neutrophils(NEU),lymphocytes(LYM),neutrophil to lymphocyte ratio(NLR)of each group were tested.The test results were statistically analyzed.Results The levels of CEA,SCC,CA-199,CA-125,and CYFRA21-1 in the study group were(2.56±0.84)ng/mL,(0.91±0.28)ng/mL,(7.34±2.36)U/mL,(7.06±2.65)U/mL,(3.32±1.42)ng/mL and were significantly higher than those in the control group,the difference was statistically significant(t=19.325,7.126,14.462,7.858,15.712,P<0.05).The NEU,LYM,and NLR of the study group were(5.44±2.34)×10^(9)/L,(1.28±0.51)×10^(9)/L,(5.41±4.35)respectively and were significantly higher than those of the control group,the difference was statistically significant(t=10.270,7.294,6.126,P<0.05).In the lung squamous cell carcinoma group,CEA level was(1.55±0.70)ng/mL,SCC level was(0.92±0.26)ng/mL,CA-199 level was(6.03±1.95)U/mL,CA-125 level was(6.03±1.73)U/mL,CYFRA21-1 level was(3.02±1.55)ng/mL.In lung adenocarcinoma group,CEA level was(2.58±0.72)ng/mL,SCC level was(0.80±0.23)ng/mL,CA-199 level was(7.64±2.36)U/mL,CA-125level was(7.82±2.11)U/mL,CYFRA21-1level was(3.38±1.21)ng/mL.The level of CEA,CA-199,CA-125 of the lung squamous cell carcinoma group were significantly lower than those of the lung adenocarcinoma group.The level of SCC of the lung squamous cell carcinoma group was significantly higher than that of the lung adenocarcinoma group,the difference was statistically significant(t=7.767,2.711,3.845,4.067,P<0.05),there was no statistical difference in the level of CYFRA21-1 between the two groups(P>0.05).NEU level in the lung squamous cell carcinoma group was(5.65±2.69)×10^(9)/L.LYM level was(1.20±0.50)×10^(9)/L.NLR was(6.13±5.20).NEU level in the lung adenocarcinoma group was(5.22±2.18)×10^(9)/L.LYM level was(1.35±0.50)×10^(9)/L.NLR was(4.69±3.40),there was no statistical difference between the two groups(t=0.995,1.617,1.955,P>0.05).Conclusion Serum tumor markers combined with blood inflammatory indicators combined is very valuable in non-small cell lung cancer,and it is worthy of clinical application.