依达拉奉联合银杏达莫治疗2型糖尿病合并急性脑梗死的临床效果分析

Analysis of the Clinical Effect of Edaravone Combined with Ginkgo Leaf Extract and Dipyridamole in the Treatment of Type 2 Diabetes Complicated with Acute Cerebral Infarction

目的探究2型糖尿病合并急性脑梗死患者应用依达拉奉联合银杏达莫的治疗效果。方法选择2018年12月—2020年12月山东省日照市中心医院、山东省日照市中医医院以及山东省日照市人民医院收治的2型糖尿病合并急性脑梗死患者80例。使用随机数表法分对照组、观察组,各40例。对照组采用常规糖尿病治疗方案+银杏达莫治疗,观察组采用常规糖尿病治疗方案+银杏达莫联合依达拉奉治疗。比较两组患者临床疗效、治疗期间神经功能缺损状况以及治疗前后血糖水平、椎基底动脉血流速度。结果观察组患者临床显效率(95.00%)高于对照组,差异有统计学意义(χ^(2)=5.165,P<0.05)。观察组患者治疗第6天、治疗第12天的神经功能缺损评分(12.89±2.04)分、(8.42±1.88)分均低于对照组,差异有统计学意义(t=5.656、8.768,P<0.05)。观察组患者治疗后空腹血糖、餐后2 h血糖、糖化血红蛋白值(5.35±0.66)mmol/L、(7.76±0.86)mmol/L、(5.62±0.52)%均低于对照组,差异有统计学意义(t=5.932、3.799、6.487,P<0.05)。在治疗后,观察组的左侧椎动脉血流速度、右侧椎动脉血流速度、基底动脉血流速度(36.54±2.48)、(35.45±4.32)、(55.66±3.86)cm/s均高于对照组,差异有统计学意义(t=13.849、4.936、5.262,P<0.05)。结论2型糖尿病合并急性脑梗死患者治疗中,应用依达拉奉联合银杏达莫治疗效果显著,可有效改善其动脉血流速度,在控制血糖基础上减少神经系统损伤。

Objective To explore the treatment effects of edaravone combined with ginkgo leaf extract and dipyridamole in patients with type 2 diabetes and acute cerebral infarction.Methods A total of 80 patients with type 2 diabetes and acute cerebral infarction admitted to Rizhao Central Hospital of Shandong Province,Rizhao City Traditional Chinese Medicine Hospital of Shandong Province and Rizhao City People's Hospital of Shandong Province from December 2018 to December 2020 were selected.They were divided into the control group and the observation group by random number table method,with 40 patients in each group.The control group was treated with conventional diabetes treatment solution combined with ginkgo leaf extract and dipyridamole.The observation group was treated with conventional diabetes treatment solution and ginkgo Damo combined with edaravone.Clinical effect,status of neurological deficits during treatment,and blood glucose levels and vertebrobasilar blood flow velocities before and after treatment were compared between the two groups.Results The clinical effective rate of the observation group was 95.00%higher than that of the control group,and the difference was statistically significant(χ^(2)=5.165,P<0.05).The neurological deficit scores of the patients in the observation group on the 6th day and the 12th day after treatment were(12.89±2.04)points and(8.42±1.88)points lower than those in the control group,and the differences were statistically significant(t=5.656,8.768,P<0.05).The fasting blood glucose,2 h postprandial blood glucose,and glycosylated hemoglobin values of the observation group after treatment were(5.35±0.66)mmol/L,(7.76±0.86)mmol/L,and(5.62±0.52)%lower than those of the control group,and the differences were statistically significant(t=5.932,3.799,6.487,P<0.05).After treatment,the left vertebral artery blood flow velocity,right vertebral artery blood flow velocity and basilar artery blood flow velocity in the observation group were all higher(36.54±2.48)cm/s,(35.45±4.32)cm/s,(55.66±3.86)cm/s compared with the control group,the difference was statistically significant(t=13.849,4.936,5.262,P<0.05).Conclusion The application of edaravone combined with ginkgo leaf extract and dipyridamole in the treatment of type 2 diabetes mellitus patients with acute cerebral infarction has a significant effect,which can effectively improve arterial blood flow velocity and reduce neurological damage on the basis of blood glucose control.It is worth promoting.