以蛋白质为基础物质的姜黄素传递体系研究进展

Research Progress on Protein-based Delivery Systems for Curcumin

传递体系通常被设计用于包埋功能活性物质,提高活性物质的稳定性和生物利用度,进而克服其应用障碍。天然食品来源的蛋白质生物相容性好、无毒、可降解,是构建食品级传递体系的优良基础物质。本文以典型的疏水性、低稳定、低生物利用率的功能活性物质——姜黄素为代表,介绍以蛋白质为基础物质的姜黄素传递体系的构建原料、制备方法、作用机理及体系类型,并对其发展前景进行展望。

Delivery systems are usually designed to encapsulate bioactive compounds for improving its stability,bioavailability,and tackling their application obstacles.Natural food proteins are biocompatible,non-toxic and biodegradable materials,which are excellent building blocks for food-grade delivery systems.In this paper,curcumin,a typical functional bioactive compound which exhibited high hydrophobicity,low stability,and poor bioavailability was taken as a representative,the raw materials,fabrication methods,interaction mechanisms and different types of protein-based curcumin delivery systems were reviewed.Finally,the development of protein-based curcumin delivery systems were also prospected.