研究白细胞介素(IL)及C反应蛋白(CRP)对老年心血管急症的临床诊断价值

Study on the Clinical Diagnostic Value of Interleukin(IL)and C-Reactive Protein(CRP)in Elderly Cardiovascular Emergencies

目的分析C反应蛋白(CRP)和白细胞介素(IL)在老年心血管急症中的诊断价值。方法回顾性分析2019年5月—2021年5月该院收治的50例老年心血管急症患者作为研究组,选取同期50名健康的体检者作为参照组。比较参照组体检者与研究组患者的白细胞介素水平,N末端B型利钠肽原(NT-proBNP),同型半胱氨酸以及C反应蛋白水平,谷胱甘肽过氧化酶(GSHPX),超氧化物歧化酶(SOD),丙二醛(MDA)水平,氧化酶亚基gp91、p67、p47、p22水平,内皮素-1(ET-1),肿瘤坏死因子(TNF-α)水平,心肌肌钙蛋白T(cTnT)和胱抑素C(CysC)水平。结果参照组体检者的IL-1水平(21.01±2.33)pg/L低于研究组患者的(31.31±4.91)pg/L,差异有统计学意义(t=13.401,P<0.001)。参照组体检者的NT-proBNP、Hcy及CRP水平均低于研究组患者,差异有统计学意义(P<0.05)。参照组体检者的GSHPX与SOD水平均高于研究组患者,而MDA水平低于研究组患者,差异有统计学意义(P<0.05)。参照组体检者的gp91、p67、p47、p22水平均低于研究组患者,差异有统计学意义(P<0.05)。参照组体检者的内皮素受体、ET-1及TNF-α水平均低于研究组患者,差异有统计学意义(P<0.05)。参照组体检者的cTnT和CysC水平均低于研究组患者,差异有统计学意义(P<0.05)。结论对于老年心血管急症的患者来讲,其CRP和IL水平升高与患者发病有关,并且还有氧化酶参与其中。

Objective To analyze the diagnostic value of C-reactive protein(CRP)and interleukin(IL)in elderly cardiovascular emergencies.Methods 50 elderly patients with cardiovascular emergencies treated in the hospital from May 2019 to May 2021 were retrospectively analyzed as the study group,and 50 healthy physical examiners in the same period were selected as the reference group.The levels of interleukin,N-terminal pro-B-type natriuretic peptide(NT-proBNP),homocysteine(Hcy)and C-reactive protein,levels of glutathione peroxidase(GSHPX),superoxide dismutase(SOD),and malondialdehyde(MDA),levels of oxidase subunits gp91,p67,p47,p22,endothelin-1(ET-1)and Tumor necrosis factor(TNF-α)levels,cardiac troponin T(cTnT)and cystatin C(CysC)levels were compared between the reference group and the study group.Results The IL-1 levels of the examiners in the reference group(21.01±2.33)pg/L were lower than those in the study group(31.31±4.91)pg/L,the difference was statistically significant(t=13.401,P<0.001).The NT-proBNP,Hcy and CRP levels of the subjects in the reference group were lower than those in the study group,the difference was statistically significant(P<0.05).The levels of GSHPX and SOD in the reference group were higher than those in the study group,while the MDA level was lower than that in the study group,the difference was statistically significant(P<0.05).The levels of gp91,p67,p47 and p22 in the reference group were lower than those in the study group,the difference was statistically significant(P<0.05).The levels of endothelin receptor,ET-1 and TNF-αin the reference group were lower than those in the study group,the difference was statistically significant(P<0.05).The cTnT and CysC levels of the subjects in the reference group were lower than those in the study group,the difference was statistically significant(P<0.05).Conclusion For elderly patients with cardiovascular emergencies,elevated levels of CRP and IL are associated with the disease,and oxidase is also involved.