腹腔镜前列腺癌根治术在前列腺癌治疗中对患者临床指标改善及雄激素水平、免疫功能影响研究

Effect of Laparoscopic Radical Prostatectomy on the Improvement of Clinical Indexes,Androgen Levels and Immune Function in Patients with Prostate Cancer Treatment

目的探析前列腺癌患者在腹腔镜下实施根治术的临床效果及对相关指标水平影响。方法回顾性分析2018年12月—2020年12月70例前列腺癌患者的临床资料,根据治疗术式的不同进行分组,应用开放性前列腺癌根治术治疗的35例患者作为对照组,应用腹腔镜前列腺癌根治术治疗的35例患者作为观察组,比较两组治疗效果。结果观察组治疗后双氢睾酮(DHT)(573.14±10.32)ng/L、游离睾酮(FT)水平(0.45±0.10)nmol/L均高于对照组,差异有统计学意义(t=9.429、5.667,P<0.001);观察组治疗后T淋巴细胞亚群中CD4+(27.59±2.08)%、CD8+(26.51±2.02)%高于对照组,差异有统计学意义(t=4.464、4.747,P<0.001)。观察组治疗后最大尿流率(18.89±2.00)mL/s大于对照组,差异有统计学意义(t=6.610,P<0.001),而残余尿量(11.52±1.27)mL、IPSS评分(7.42±1.01)分低于对照组,差异有统计学意义(t=9.013、6.347,P<0.001)。结论基于腹腔镜下开展前列腺癌根治术,对机体微循环影响小,有助于提升最大尿流率和前列腺功能,短期疗效理想。

Objective To explore the clinical effect of laparoscopic radical resection in patients with prostate cancer and its influence on related index levels.Methods The clinical data of 70 patients with prostate cancer were retrospectively analyzed from December 2018 to December 2020 and grouped according to different treatment methods.35 patients treated with open radical prostatectomy were used as the control group.The 35 patients treated with laparoscopic radical prostatectomy were used as the observation group,and the therapeutic effects of the two groups were compared.Results After treatment,the levels of dihydrotestosterone(DHT)(573.14±10.32)ng/L and free testosterone(FT)(0.45±0.10)nmol/L in the observation group were higher than those in the control group,the difference was statistically significant(t=9.429,5.667,P<0.001);CD4+(27.59±2.08)%and CD8+(26.51±2.02)%of T lymphocyte subsets in the observation group were higher than those in the control group,the difference was statistically significant(t=4.464,4.747,P<0.001).After treatment,the maximum urinary flow rate(18.89±2.00)mL/s of the observation group was higher than that of the control group,the difference was statistically significant(t=6.610,P<0.001),while the residual urine volume(11.52±1.27)mL and IPSS score(7.42±1.01)points were lower than those of the control group groups,the difference was statistically significant(t=9.013,6.347,P<0.001).Conclusion Based on laparoscopic radical prostatectomy,which has little impact on the body's microcirculation,it is helpful to improve the maximum urinary flow rate and prostate function,and the short-term effect is ideal.