来那度胺联合硼替佐米和地塞米松治疗多发性骨髓瘤的疗效观察

Efficacy of lenalidomide combined with bortezomib and dexamethasone in the treatment of multiple myeloma

目的探讨来那度胺联合硼替佐米和地塞米松治疗多发性骨髓瘤的疗效观察。方法选取2016年1月至2020年1月间西电集团医院收治的80例多发性骨髓瘤患者,采用双盲法抽签分为观察组和对照组,每组40例。对照组患者采用硼替佐米+地塞米松治疗,观察组患者在对照组基础上联合来那度胺治疗,比较两组患者治疗前后的血清钙磷水平、细胞免疫功能及血液指标。结果治疗后,两组患者血清钙和磷水平均下降,且观察组均低于对照组,差异均有统计学意义(均P<0.05)。治疗后,两组患者CD3^(+)及CD4^(+)指标均提升,且观察组高于对照组,两组患者CD8^(+)指标均下降,且观察组低于对照组,差异均有统计学意义(均P<0.05)。治疗后,两组患者M蛋白和β_(2)微球蛋白水平均下降,且观察组低于对照组,差异均有统计学意义(均P<0.05)。结论多发性骨髓瘤患者采用来那度胺联合硼替佐米、地塞米松治疗,可改善患者血清钙磷水平和血液指标,调节机体免疫功能。

Objective To investigate the efficacy of lenalidomide combined with bortezomib and dexamethasone in the treatment of multiple myeloma.Methods A total of 80 patients with multiple myeloma admitted to Xidian Group Hospital were selected from January 2016 to January 2020.The double-blind method was used to divide them into an observation group and a control group with 40 patients in each group.The observation group received lenalidomide combined with bortezomib and dexamethasone and the control group received bortezomib and dexamethasone.Serum calcium and phosphorus levels,cellular immune function and blood indexes were compared between the two groups before and after the treatment.Results Serum calcium and phosphorus levels decreased in the two groups after the treatment,and these levels were lower in the observation group than in the control group(all P<0.05).The CD3^(+) and CD4^(+) levels increased in the two groups after treatment,and the levels of CD3^(+) and CD4^(+) were higher in the observation group than in the control group(all P<0.05).CD8^(+) level decreased in the two groups,and it was lower in the observation group than in the control group(P<0.05).The levels of M protein and β_(2)-microglobulin decreased in the two groups after the treatment,and the levels were lower in the observation group than in the control group(all P<0.05).Conclusion The treatment of lenalidomide combined with bortezomib and dexamethasone can improve serum calcium and phosphorus levels,regulate the immune function,and improve blood indicators in patients with multiple myeloma.