血清铁蛋白及其与感染的研究进展

Progress of serum ferritin and its relationship with infection

铁蛋白是由不同铁蛋白亚基组成的用以储存人体铁元素的多聚体蛋白,参与维持细胞内外铁平衡,当机体感染时,铁平衡受到内外因素影响被打破。研究表明,铁蛋白在感染时会显著升高,并可能影响疾病的预后。但由于对铁蛋白认识不足,目前临床上对于铁蛋白研究较少,该文旨在从铁蛋白循环、感染时的铁紊乱、血清铁蛋白对感染性疾病的预测和预后影响等方面对血清铁蛋白及其与感染的关系进行综述。

Ferritin is a polymeric protein composed of different ferritin subunits to store iron in the human body.It is involved in maintaining iron balance inside and outside the cell.Iron balance is disrupted by internal and external factors after infection.Studies have shown that ferritin is significantly elevated during infection and may affect the prognosis of the disease.However,due to insufficient understanding of ferritin,the study on ferritin is rarely in the clinic.This article aims to review the relationship between serum ferritin and infection from the aspects of the ferritin cycle,iron disturbance during infection,prediction,and prognosis of serum ferritin in infectious diseases,and provide a reference for further research.