肺泡呼出气一氧化氮在儿童肺疾病中的应用进展

Progress in application of alveolar exhaled nitric oxide in pediatric lung diseases

呼出气一氧化氮被认为是气道炎症的生物标志物,其中表征小气道炎症的肺泡呼出气一氧化氮(alveolar exhaled nitric oxide,CaNO)越来越多地被应用于呼吸系统疾病中。CaNO不仅可以应用于儿童支气管哮喘严重程度的评估、治疗方案的选择以及治疗效果的动态监测,还可以应用于间质性肺疾病的早期诊断及肺损害严重程度的评估,对于肺结核、肺动脉高压等其他疾病的诊断方面可能也有很大的帮助。该文就CaNO在儿童呼吸系统疾病的诊断及治疗指导价值作一综述,探讨CaNO在儿童肺部疾病中的诊断及治疗效果评估作用。

As a biomarker of airway inflammation,alveolar exhaled nitric oxide(CaNO),which represents small airway inflammation,is increasingly used in respiratory diseases.CaNO not only can be applied to children bronchial asthma severity evaluation,the selection of treatment and treatment effect of the dynamic monitoring,can also be applied to the early diagnosis of interstitial lung disease and assessment of the severity of lung damage for other diseases such as tuberculosis,pulmonary hypertension diagnosis.This paper reviews the diagnostic and therapeutic value of CaNO in pediatric respiratory diseases,and discusses the role of CaNO in the diagnosis and therapeutic evaluation in pediatric lung diseases.