未分化结缔组织病合并妊娠的研究进展

Research advances on undifferentiated connective tissue disease in pregnant women

未分化结缔组织病(UCTD)具有结缔组织病的临床和实验室特征,但又不能满足于任何一种特定的结缔组织病的诊断标准。UCTD是妊娠期女性最常见的结缔组织病之一,可使妊娠不良事件的风险增加,如自然流产、先兆子痫、胎儿生长受限、小于胎龄儿、反复种植失败等,而妊娠又可导致UCTD病情复发、加重,甚至出现严重并发症。合理治疗和严密的多学科监测可改善妊娠结局。

Undifferentiated connective tissue disease(UCTD)has clinical and laboratory characteristics of connective tissue disorders,but it can not meet the diagnostic criteria of any specific disease.Pregnancy complicated with UCTD is one of the most common rheumatic diseases in women of childbearing age.UCTD will increase the risk of adverse events of pregnancy,such as spontaneous abortion,preeclampsia,fetal growth restriction,small for gestational age,recurrent implantation failure and so on.Pregnancy may lead to recurrence,aggravation and even serious complications of UCTD;multidisciplinary monitoring and appropriate treatment can improve the pregnancy outcome.