食管癌围术期免疫检查点抑制剂致肺损伤二例

Lung injury caused by perioperative immune checkpoint inhibitors in esophageal cancer:two case report

免疫治疗被认为是针对各种类型癌症的较为有效的治疗策略,也已成为食管癌治疗的主要手段。本文分析2例食管癌术后的患者,使用免疫检查点抑制剂后出现免疫相关肺炎,经对症治疗后出现不同的结局,结合文献进行讨论,提示临床应用免疫检查点抑制剂时,应警惕肺部反应,早诊断,早治疗,以期能改善患者预后。

Immunotherapy has been regarded as a relatively effective therapeutic strategy for various types of cancer and has become the main means for the treatment of esophageal cancer.In this paper,analyzed two cases of patients with postoperative esophageal cancer who developed immune-associated pneumonia after the use of immunosuppressants and had different outcomes after symptomatic treatment.Combining with literature discussion,it is suggested that clinicians should be vigilant of pulmonary reactins during application of immunosupressants,and early diagnosis and early treatment,are necessary to improve the prognosis of patients.