丘脑底核-苍白球外侧-脚桥核网络的振荡动力学分析

Analyses of Oscillation Dynamics in a Subthalamic Nucleus-External Globus Pallidus-Pedunculopontine Nucleus Network

基底神经节(BG)是大脑深部一系列神经核团所构成的功能整体,参与精巧运动的形成.BG中丘脑底核(STN)和苍白球(GP)的异常同步振荡被认为与帕金森病(PD)有关.建立丘脑底核-苍白球外侧-脚桥核(STN-GPe-PPN)模型,基于稳定性理论给出了模型产生振荡的稳定性条件,探讨PPN和STN之间的耦合强度对STN-GPe振荡的影响,并分析GPe与STN之间的传输时滞对STN振荡的影响.数值模拟结果表明,丘脑底核受到脚桥核相互之间较强的促进作用和苍白球外侧较大的传输时滞时,丘脑底核会产生更高振幅的振荡.

The basal ganglia(BG) is a functional whole composed of a series of nuclei in the deep part of the brain, which is involved in the formation of exquisite movements.The abnormal synchronous oscillation of subthalamic nucleus(STN) and globus pallidus(GP) in BG is considered to be related to Parkinson’s disease(PD).A subthalamic nucleus-external globus pallidus-pedunculopontine nucleus(STN-GPe-PPN) model was established.Based on the stability theory, the stability condition for the oscillation of the network was given.The effect of the coupling strength between PPN and STN on STN-GPe oscillations and the effect of the transmission time delay between GPe and STN on STN oscillations were investigated.The numerical simulation results showed that the STN generated higher amplitude oscillations when the subthalamic nucleus was subjected to stronger facilitation between the pedunculopontine nucleus and subthalamic nucleus.In addition, larger transmission time delay in the external globus pallidus, the higher amplitude oscillations of STN.