超重肥胖和2型糖尿病对瘦素、内脂素的影响研究

Effects of overweight/obesity and type 2 diabetes mellitus on leptin and visfatin levels

目的探讨超重肥胖和2型糖尿病(T2DM)对瘦素、内脂素的影响。方法选择2017年1-6月在丽水市中心医院住院治疗的男性T2DM患者和参加健康体检的男性非T2DM患者为研究对象。收集年龄、疾病史等基本资料,测量身高、体重并计算体质指数(BMI),检测瘦素和内脂素等指标。比较T2DM患者和非T2DM患者,超重肥胖患者和非超重肥胖患者的瘦素、内脂素水平;并采用广义线性模型分析超重肥胖与T2DM交互作用对瘦素、内脂素的影响。结果T2DM患者66例,年龄为(49.70±9.45)岁,糖尿病病程为(4.99±4.46)年;非T2DM患者64人,年龄为(43.89±0.20)岁。T2DM患者瘦素和内脂素水平分别为(3.17±0.36)和(29.14±3.16)ng/mL,高于非T2DM患者的(3.03±0.30)和(21.81±3.32)ng/mL(t=2.387,P=0.018;t=12.900,P<0.001)。检出超重肥胖患者66例,非超重肥胖患者64人。超重肥胖患者瘦素水平为(3.27±0.32)ng/mL,高于非超重肥胖患者的(2.92±0.26)ng/mL(t=6.634,P<0.001);内脂素水平为(24.38±5.14)ng/mL,低于非超重肥胖患者的(26.71±4.36)ng/mL(t=2.780,P=0.006)。广义线性模型分析结果显示,超重肥胖与T2DM对瘦素(β=0.286,P=0.003)、内脂素(β=2.709,P=0.008)的影响存在交互作用。结论超重肥胖与T2DM交互作用影响瘦素、内脂素水平。

Objective To investigate the effects of the link between overweight/obesity and type 2 diabetes mellitus(T2DM)on leptin and visfatin levels.Methods Males without T2DM and male patients with T2DM hospitalized in Li⁃shui Municipal Central Hospital from January to June,2017 were enrolled.Subjects'age and medical history of diseas⁃es were collected.The height and body weight were measured,and the body mass index(BMI)was estimated.The leptin and visfatin levels were determined,and compared between patients with and without T2DM,and between pa⁃tients with and without overweight/obesity.The effect of the link between overweight/obesity and T2DM on leptin and visfatin levels was examined using a generalized linear regression model.Results There were 66 patients with T2DM,with a mean age of(49.70±9.45)years and a mean diabetes duration of(4.99±4.46)years,and there were 64 patients without T2DM,with a mean age of(43.89±0.20)years.The leptin[(3.17±0.36)vs.(3.03±0.30)ng/mL;t=2.387,P=0.018]and visfatin levels[(29.14±3.16)vs.(21.81±3.32)ng/mL;t=12.900,P<0.001]were significantly greater in T2DM patients than in patients without T2DM.The leptin level was significantly greater in patients with overweight/obesity than in those without overweight/obesity[(3.27±0.32)vs.(2.92±0.26)ng/mL;t=6.634,P<0.001],and the visfatin level was significantly lower in patients with overweight/obesity than in those without overweight/obesity[(24.38±5.14)vs.(26.71±4.36)ng/mL;t=2.780,P=0.006].Generalized linear regression analysis showed interacting effects of overweight/obesity and T2DM on leptin(β=0.286,P=0.003)and visfatin levels(β=2.709,P=0.008).Conclusion The interaction be⁃tween overweight/obesity and T2DM affects leptin and visfatin levels.