基于中医传承辅助平台分析尹建平治疗慢性疲劳综合征的用药规律

Analysis of YIN Jianping’s medication rule for chronic fatigue syndrome based on the auxiliary platform of Chinese medicine inheritance

目的:探讨及分析尹建平教授治疗慢性疲劳综合征(Chronic Fatigue Syndrome,CFS)的用药经验。方法:采用中医传承辅助平台(V2.5)统计尹师诊治CFS的有效处方,统计药物频次、四气五味归经、常用药对频次,并基于关联规则分析处方规律,聚类形成核心治疗组合及新处方分析。结果:共筛选出205首处方,89味中药;使用频次排名前20的中药主要类型为补虚类、健脾化湿类、利水渗湿类;药物四气五味及归经分析结果显示,所用药物以温性、寒性,辛、苦、甘味为主,药物主要归脾、胃、肺、肝经,在常用药对分析上以益气升阳、健脾利湿、疏肝健脾为主,并根据系统聚类分析获得10对核心药物组合、5对药物新处方。结论:尹师认为“湿邪致虚”贯穿CFS始终,临床主张“以通为补”的治疗思路,重视固护脾胃,强调“祛湿而不伤正,养阴而不留湿”。

Objective:To explore and analyze Professor YIN Jianping’s experience in treating chronic fatigue syndrome.Methods:The Traditional Chinese Medicine Inheritance Auxiliary Platform(V2.5)was used to count Master YIN’s effective prescriptions for diagnosis and treatment of chronic fatigue syndrome,the frequency of medicines,the return of four Qi(气)and five flavors,and the frequency of commonly used medicine pairs.The prescription rules were analyzed based on association rules,and the core treatment combinations and new prescriptions analysis were formed by clustering.Results:A total of 205 prescriptions and 89 TCM medicines were screened out;the main types of TCM medicines ranked top 20 in frequency of use were tonic,spleen and dampness,diuresis and dampness;the analysis results of four Qi and five flavors and the meridian of the drugs showed that the used medicines are mainly warm,cold,pungent,bitter,and sweet.The medicines mainly belong to the spleen,stomach,lung,and liver meridian.In the analysis of commonly used medicines,they are mainly used for replenishing Qi and promoting Yang(阳),strengthening the spleen and promoting dampness,soothing the liver and strengthening the spleen.10 pairs of core drug combinations and 5 pairs of new drug prescriptions were obtained based on the systematic cluster analysis.Conclusion:Master YIN believes that“dampness caused by dampness”runs through the chronic fatigue syndrome,and clinically advocates the treatment idea of“take dredge as nourish”,emphasizes the strengthening of the spleen and stomach,and emphasizes“eliminating dampness without hurting body resistance,nourishing Yin(阴)without leaving dampness”.